LEKARZ KATOWICE

<h1 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 30px; font-stretch: inherit; font-weight: 500; line-height: 30px; margin: 0px 0px 20px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.</span></span><span style="margin: 0px; padding: 0px;"> DIAGNOSTYKA OCENA</span></h1>
<h2 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 17px; font-stretch: inherit; font-weight: 500; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span style="border: 0px; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.1.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Badania przesiewowe i wczesne wykrywanie</span></span></span></h2>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Populacja lub masa przesiewowe definiuje się jako systematyczne badanie bezobjawowych mężczyzn (ryzyka) i jest zwykle inicjowane przez władze sanitarne. </span><span style="margin: 0px; padding: 0px;">W przeciwieństwie do wczesnego wykrywania lub badania oportunistyczne (ad-hoc) składa się z indywidualnych ustaleń przypadków, które są inicjowane przez człowieka podlega badaniu (pacjent) i / lub jego lekarza. </span><span style="margin: 0px; padding: 0px;">Cele współpracujące podstawowej obu strategii są:</span></span></div>
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<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Zmniejszenie śmiertelności z powodu PCa;</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">co najmniej, prowadzi jakości życia (QoL z) wyrażone przez QoL skorygowane zyski w latach życia (QUALYS).</span></li>
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<span style="margin: 0px; padding: 0px;">Rak prostaty trendy umieralności zakresu szeroko od kraju w świecie uprzemysłowionym [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_34" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">34</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Śmiertelność z powodu PCa spadła w większości krajów zachodnich, ale skala redukcji waha się w poszczególnych krajach. </span><span style="margin: 0px; padding: 0px;">Zmniejszona śmiertelność sortuje w USA uważa się częściowo ze względu na powszechnie przyjętą agresywnych PCa polityki przesiewowych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_35" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">35</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Jednak nadal nie ma dowodów, że poziom 1 PSA masowe badania przesiewowe jest opłacalne w zmniejszaniu PCA śmiertelność [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_36" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">36</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Obecnie badania przesiewowe dla PCa jest jednym z najbardziej kontrowersyjnych tematów w urologicznej literaturze [</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_37" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">37</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Trzy duże prospektywne RCT opublikowane dane na temat badań przesiewowych w 2009 roku [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_38-40" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">38-40</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Podgrzewane dyskusje i debaty spowodowało wiele sprzecznych stanowisk i policy papers. </span><span style="margin: 0px; padding: 0px;">Niektórzy autorzy twierdzą, że korzystanie z obecnych amerykańskich Towarzystwa Urologicznego (AUA) wytycznych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_41" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">41</span></a><span style="margin: 0px; padding: 0px;"> ] lub US Preventive zaleceń Services Task Force for przesiewowych [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_42" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">42</span></a><span style="margin: 0px; padding: 0px;"> ] może prowadzić do znacznej liczby mężczyzn z agresywną chorobą są brakowało [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_43" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">43</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_44" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">44</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Ostatnio porównanie systematyczny i oportunistyczne przesiewowych zasugerował nadmiernej diagnozy i zmniejszenie śmiertelności w grupie systematycznych badań przesiewowych w porównaniu do wyższej nadmiernej diagnozy z marginalnej korzyści przetrwania w najlepszym razie, w oportunistycznym schematu badań przesiewowych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_45" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">45</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Potencjalny wpływ tego tematu wymagałoby najwyższy poziom dowodów przedstawionych przez systematycznego przeglądu literatury wszystkich opublikowanych badań lub kohort podsumowane w metaanalizie. </span><span style="margin: 0px; padding: 0px;">Analiza podgrup z kohort, które są częścią dużych badaniach, czy projekcje matematycznych sam, nie może zapewnić jakość dowodów potrzebnych do właściwego rozwiązania tego pytanie kliniczne.</span></span></div>
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<span style="margin: 0px; padding: 0px;">W przeglądzie Cochrane opublikowana w 2013 roku [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_36" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">36</span></a><span style="margin: 0px; padding: 0px;"> ], który został zaktualizowany od [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_46" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">46</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] przedstawia główny przegląd. </span><span style="margin: 0px; padding: 0px;">Wyniki zaktualizowanego wydania (na podstawie przeglądu literatury do dnia 3 kwietnia 2013) są niemal identyczne z przeglądu 2013:</span></span></div>
<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Screening jest związana ze zwiększonym diagnozy PCA (RR: 1,3; 95% CI: 1.02-1.65).</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Screening jest związany z wykryciem bardziej zlokalizowane choroby (RR: 1,79; 95% CI: 1.19-2.70) oraz mniej zaawansowane PCa (T3-4, N1, M1) (RR: 0,80; 95% CI: 0.73-0.87).</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Na podstawie wyników z pięciu RCT doborze losowym ponad 341.000 ludzi, ma korzyść w zakresie przeżycia PCa specyficzne zaobserwowano (RR: 1,00, 95% CI: 0.86-1.17). </span><span style="margin: 0px; padding: 0px;">To było głównym punktem końcowym w tych badaniach.</span></span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Na podstawie wyników czterech dostępnych badań z randomizacją, bez całkowitego przeżycia (OS) zaobserwowano korzyści  </span><br style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px; padding: 0px;" /><span style="margin: 0px; padding: 0px;">(RR: 1,00; 95% CI: 0.96-1.03).</span></li>
</ul>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Co więcej, badania przesiewowe wiązało się z mniejszych i większych szkód, takich jak nadmierne diagnozy i ponad-leczenia. </span><span style="margin: 0px; padding: 0px;">Nieoczekiwanie stwierdzono, że narzędzie diagnostyczne (np biopsji) nie wiązała się z śmiertelności w wybranych papierów, który w przeciwieństwie do innych danych znanych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_26" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">26</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_27" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">27</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Jej wpływ na ogólną jakość życia pacjenta jest nadal niejasny [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_47-49" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">47-49</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ], jednak badania przesiewowe nie wykazano, aby być szkodliwe na poziomie populacji. </span><span style="margin: 0px; padding: 0px;">Wszystkie te odkrycia doprowadziły do silnego poradę przed systematycznym populacyjnych badań przesiewowych opartych we wszystkich krajach, w tym w Europie.</span></span></div>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Od 2013 roku, Europejskie Badanie randomizowane badania przesiewowe w kierunku raka prostaty (ERSPC) dane zostały zaktualizowane 13 latach obserwacji (patrz tabela 5.1.1) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_50" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">50</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Kluczowym przesłaniem jest to, że o rozszerzonym śledzić, zmniejszenie śmiertelności pozostaje bez zmian (21% i 29% po korekcie niezgodności).</span><span style="margin: 0px; padding: 0px;">Jednakże liczba potrzebna do przeszukiwania i traktować maleje, a obecnie znajduje się poniżej numer potrzebny do ekranu obserwowane w badaniach raka piersi [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_51" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">51</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.1.1 dane obserwacyjne z ERSPC badaniu  </span><span class="bodytekst" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">[ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_50" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">50</span></span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]</span></span></span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Lata obserwacji</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Ilość potrzebna do ekranu</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Ilość potrzebnego do leczenia</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
9</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
1,410</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
48</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
11</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
979</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
35</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
13</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
781</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
27</div>
</td></tr>
</tbody></table>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Zindywidualizowana strategia ryzyka dostosowane do wczesnego wykrywania mogą być oferowane do dobrze poinformowanego człowieka z co najmniej 10-15 lat życia. </span><span style="margin: 0px; padding: 0px;">Jednakże, to podejście może być nadal wiąże się ze znacznym ryzykiem nadmiernego diagnozy. </span><span style="margin: 0px; padding: 0px;">Dlatego ważne jest, aby dokładnie zidentyfikować grup pacjentów, które mogą odnieść największe korzyści z indywidualnego wczesnej diagnozy, biorąc pod uwagę potencjalne salda i szkody związane.</span></span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Mężczyźni na podwyższone ryzyko konieczności PCA są te> 50 lat lub z wywiadem rodzinnym PCA (zarówno ojcowskiej i matczynej [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_52" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">52</span></a><span style="margin: 0px; padding: 0px;"> ]) oraz wiek> 45 lat, lub Afroamerykanie [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_53" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">53</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Ponadto mężczyzn z PSA </span></span><br />
<span style="margin: 0px; padding: 0px;">> 1 ng / ml po 40 lat i> 2 ng / ml w 60 lat [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_54" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">54</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_55" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">55</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] są również narażeni na zwiększone ryzyko PCa przerzutów lub śmierci kilkadziesiąt lat później. </span><span style="margin: 0px; padding: 0px;">Przetrwanie długoterminowe i korzyści QoL takiego podejścia pozostaje do udowodnienia na poziomie populacji. </span><span style="margin: 0px; padding: 0px;">Ostatnio, jak na nowotwór sutka, nieprawidłowości genetycznych, które mogą być związane ze zwiększonym ryzykiem prospektywnych wykazano, zwłaszcza BRCA2 [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_56" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">56</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Kilka nowych markerów biologicznych, takich jak TMPRSS2-Erg fuzję PCA3, kallikreines [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_57" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">57</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_58" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">58</span></a><span style="margin: 0px; padding: 0px;"> ] lub kilka markerów genetycznych [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_59-62" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">59-62</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] Wykazano, że dodatek czułość i specyficzność w górnej PSA, obniżając przez diagnostyki. </span><span style="margin: 0px; padding: 0px;">W tej chwili nie jest zbyt ograniczone dane, aby oprzeć się na rekomendację. </span><span style="margin: 0px; padding: 0px;">Również zwiększenie przeżycia populacyjne nie została jeszcze udowodniona.</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Kalkulator ryzyka może być pomocna w celu określenia (indywidualnie), co może być potencjalnym ryzykiem raka, zmniejszając tym samym liczbę zbędnych biopsji. </span><span style="margin: 0px; padding: 0px;">Kilka narzędzi opracowanych z badań kohortowych są dostępne:</span></span></div>
<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">z PCPT kohorty: PCPTRC 2,0 </span><span class="onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><a href="http://deb.uthscsa.edu/URORiskCalc/Pages/calcs.jsp" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;" target="_blank"><span style="margin: 0px; padding: 0px;">http://deb.uthscsa.edu/URORiskCalc/Pages/calcs.jsp</span></a></span><span style="margin: 0px; padding: 0px;"> ;</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">z ERSPC kohorty:  </span><span class="onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><a href="http://www.prostatecancer-riskcalculator.com/seven-prostate-cancer-risk-calculators" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;" target="_blank"><span style="margin: 0px; padding: 0px;">http://www.prostatecancer-riskcalculator.com/seven-prostate-cancer-risk-calculators</span></a></span><span style="margin: 0px; padding: 0px;">;</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">z lokalnego kanadyjskiego grupie:  </span><span class="onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><a href="http://sunnybrook.ca/content/?page=occ-prostatecalc" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;" target="_blank"><span style="margin: 0px; padding: 0px;">http://sunnybrook.ca/content/?page=occ-prostatecalc~~HEAD=pobj</span></a></span><span style="margin: 0px; padding: 0px;">(między innymi).</span></li>
</ul>
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<span style="margin: 0px; padding: 0px;">Ponieważ żaden wyraźnie pokazał wyższość pozostaje osobistą decyzję, który z nich korzystać [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_63" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">63</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Dobrze poinformowani ludzie wnioskiem wczesną diagnozę należy test PSA i przejść badanie palpacyjne (DRE) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_64" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">64</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Optymalne przedziały dla testów PSA i DRE obserwacji nie są znane, gdyż wahał się od kilku prospektywnych badań.</span><span style="margin: 0px; padding: 0px;">Strategia ryzyka dostosowana może być uznane na podstawie początkowego poziomu PSA. </span><span style="margin: 0px; padding: 0px;">To może być co 2 lata dla tych, początkowo zagrożone lub odroczone do 8-10 lat w nie osoby zagrożone [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_65" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">65</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Wiek, w którym wczesna diagnoza powinna być zatrzymana pozostaje kontrowersyjna, ale średnia długość życia danej osoby musi bezwarunkowo być brane pod uwagę. </span><span style="margin: 0px; padding: 0px;">Mężczyźni, którzy mają mniej niż długość życia 15 lat raczej nie skorzystają na podstawie danych pochodzących z obrotu a ERSPC prób. </span><span style="margin: 0px; padding: 0px;">Ponadto, chociaż nie jest prostym narzędziem do oceny indywidualnej długości życia, choroby współistniejące jest co najmniej tak samo ważne jak wiek.</span><span style="margin: 0px; padding: 0px;">Szczegółowy przegląd można znaleźć w rozdziale 6.7 na starszych dorosłych i niedawno zaktualizowanych wytycznych SIOG [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_66" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">66</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Na podstawie obecnie dostępnych narzędzi, zindywidualizowana strategia będzie zdiagnozować wiele nieznacznych uszkodzeń (ponad 50% w niektórych badaniach), z których większość nie wymaga żadnej formy aktywnego leczenia (patrz punkt 7.1, odroczone leczenie). </span><span style="margin: 0px; padding: 0px;">Ważne jest, aby uświadomić sobie, że zerwanie związku między diagnostyki i leczenia aktywnego jest jedynym sposobem, aby zmniejszyć uporczywego leczenia, jednocześnie zachowując potencjalną korzyść wczesnej diagnozy indywidualnego przypadku mężczyzn żądając od niego.</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Z publicznego punktu widzenia zdrowia, mass screening PCA nie jest wskazany. </span><span style="margin: 0px; padding: 0px;">Jednak wczesne rozpoznanie w sposób indywidualny jest możliwe na podstawie DRE i testów PSA. </span><span style="margin: 0px; padding: 0px;">Indywidualne badania przesiewowe pacjent wymaga świadomej zgody pacjenta po dogłębnym omówieniu z lekarzem na temat zalet i wad z pełną procedurą, przy uwzględnieniu czynników ryzyka pacjenta, wieku i długości życia. </span><span style="margin: 0px; padding: 0px;">Interwał dla obserwacji przesiewowych zależy od wieku i poziomu PSA bazowym.</span></span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_1_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.1.1.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Wytyczne dotyczące badań przesiewowych i wczesnego wykrywania</span></span></span></h3>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zalecenie</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie narażać ludzi do testów PSA bez doradzanie im na temat potencjalnych zagrożeń i korzyści.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
3</div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Oferujemy zindywidualizowane strategię ryzyka przystosowane dla wczesnego wykrywania, dobrze poinformowany człowiek z dobrym stanie ogólnym, a długość życia wynosi co najmniej 10-15 lat.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Oferta wczesne testy PSA u mężczyzn na podwyższone ryzyko konieczności PCA:</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyźni> 50 roku życia</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyźni> 45 lat i wywiadem rodzinnym PCA</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Afroamerykanie> 45 lat</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyzn z poziomem PSA> 1 ng / ml po 40 roku życia</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyzn z poziomem PSA> 2 ng / ml po 60 roku życia</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Oferta strategię ryzyka dostosowane (na podstawie początkowego poziomu PSA), z przerwami następczych na 2 lata dla tych, początkowo na ryzyko:</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyzn z poziomem PSA> 1 ng / ml po 40 roku życia</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mężczyzn z poziomem PSA> 2 ng / ml po 60 roku życia</span></div>
<div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Odroczyć follow-up do 8 lat w tych, którzy nie zagrożone.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">do</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Zdecyduj się na wiek, w którym wczesne rozpoznanie PCa należy przerwać w oparciu o długości życia i stanu sprawności; </span><span style="margin: 0px; padding: 0px;">mężczyźni, którzy mają długości życia o <15 a="" aby="" b.="" dane="" erspc="" font="" korzysta="" lat="" ma="" o="" obrotu="" oparciu="" pr="" prawdopodobne="" to="" w="" z=""></15></span></span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
</tbody></table>
<div class="bodytekst_italic_onder_tabel 1e regel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">ERSPC = Europejski randomizowane badanie przesiewowe; </span><span style="margin: 0px; padding: 0px;">PCa = raka prostaty; </span><span style="margin: 0px; padding: 0px;">PIVOT = Prostate Cancer</span></span></div>
<div class="bodytekst_italic_onder_tabel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Intervention Trial Versus obserwacyjne; </span><span style="margin: 0px; padding: 0px;">PSA = swoistego antygenu sterczowego.</span></span></div>
<h2 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 17px; font-stretch: inherit; font-weight: 500; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span style="border: 0px; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Diagnoza kliniczna</span></span></span></h2>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Rak prostaty jest zwykle podejrzewa na podstawie DRE i / lub poziomu PSA. </span><span style="margin: 0px; padding: 0px;">Ostateczne rozpoznanie zależy od weryfikacji histopatologicznej gruczolakoraka prostaty w próbkach rdzeni lub biopsji z przezcewkowej resekcji gruczołu krokowego (TURP) lub prostatektomii łagodnego powiększenia gruczołu krokowego (BPE).</span></span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.1.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Badanie palpacyjne</span></span></span></h3>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Większość PCA znajduje się w strefie obwodowej i może być wykryty przez DRE gdy objętość wynosi  </span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">  0,2 ml. </span><span style="margin: 0px; padding: 0px;">W  </span></span><span class="Glyph" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">~</span></span><span style="margin: 0px; padding: 0px;">18% przypadków PCa wykrywa tylko podejrzanego DRE, niezależnie od poziomu PSA [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_67" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">67</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Podejrzany DRE u pacjentów z poziomem PSA  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><</span></span><span style="margin: 0px; padding: 0px;">  2 ng / ml ma dodatnią wartość predykcyjną 5-30% [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_68" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">68</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Zaburzenia DRE wiąże się ze zwiększonym ryzykiem wyższy wynik Gleason i jest wskazaniem do biopsji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_69" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">69</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_70" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">70</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.2.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Swoistego antygenu sterczowego</span></span></span></h3>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Stosowanie PSA jako markera w surowicy zrewolucjonizował PCA diagnozę [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_71" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">71</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Antygenu specyficznego dla prostaty opar- ale nie od raka, a zatem, może być podwyższona w łagodnym przerostem gruczołu krokowego (BPH), gruczołu krokowego i innych chorób niezłośliwych. </span><span style="margin: 0px; padding: 0px;">Jako zmienną niezależną, PSA jest lepszym wskaźnikiem raka niż każdy DRE lub przezodbytniczej USG (TRUS) [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_72" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">72</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Brak uzgodnionych norm określonych pomiaru PSA [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_73" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">73</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">PSA jest ciągła parametru z wyższym poziomem, wskazując na większe prawdopodobieństwo PCA. </span><span style="margin: 0px; padding: 0px;">Wielu mężczyzn mogą być siedliskiem PCA pomimo niskiej PSA w surowicy [</span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_74" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">74</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Tabela 5.2.1 przedstawia występowanie Gleason  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">  7 PCa na niskich poziomach PSA, wykluczając optymalnego progu PSA do wykrywania niewyczuwalne, ale znaczące klinicznie PCA. </span><span style="margin: 0px; padding: 0px;">Wykorzystanie nomogramów mogą pomóc w przewidywaniu indolent PCA [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_75" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">75</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.1: Ryzyko PCa w stosunku do niskich wartości PSA</span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
PSA level (ng/mL)</div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Ryzyko PCa (%)</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Ryzyko Gleason  </span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;">  7 PCa (%)</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.0-0.5</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
6.6</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.8</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.6-1.0</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
10.1</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
1.0</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
1.1-2.0</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
17.0</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
2.0</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
2.1-3.0</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
23.9</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
4.6</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
3.1-4.0</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
26.9</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="33%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
6.7</div>
</td></tr>
</tbody></table>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_2_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;">5.2.2.1.</span>PSA density</h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Antygenu specyficznego dla prostaty gęstość jest poziomem PSA w surowicy, podzielonej przez TRUS ustalonej objętości prostaty. </span><span style="margin: 0px; padding: 0px;">Im wyższa gęstość PSA, tym bardziej prawdopodobne jest, że PCA jest istotne klinicznie (patrz punkt 6.1.3).</span></span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_2_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.2.2.</span></span><span style="margin: 0px; padding: 0px;"> Prędkość i czas podwojenia PSA</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Istnieją dwie metody pomiaru kinetyki PSA:</span></div>
<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Prędkość PSA (PSAV) absolutny roczny wzrost PSA w surowicy krwi (ng / ml / rok) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_76" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">76</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Czas podwojenia PSA (PSA-DT), który mierzy gwałtowny wzrost stężenia PSA w surowicy w czasie [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_77" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">77</span></a><span style="margin: 0px; padding: 0px;">].</span></li>
</ul>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Określonej prędkości antygen prostaty i PSA-DT może mieć wartość prognostyczną rolę w obróbce PCa [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_78" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">78</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ], ale ograniczone do diagnostyki z powodu szumu tła (całkowita objętość prostaty i BPH), różnych odstępach między oznaczeń PSA oraz przyspieszania / opóźniania PSAV i PSA-DT w czasie. </span><span style="margin: 0px; padding: 0px;">Pomiary te nie dostarczają informacji w porównaniu z samym PSA [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_79-82" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">79-82</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_2_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;">5.2.2.3.</span>Free/total PSA ratio</h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Wolne / całkowita (F / T) Współczynnik PSA mogą być wykorzystywane do rozróżniania BPH od PCA. </span><span style="margin: 0px; padding: 0px;">To stratifies ryzyko PCa u mężczyzn z</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">4-10 ng / ml łącznie PSA i negatywne DRE. </span><span style="margin: 0px; padding: 0px;">Raka prostaty wykrywa biopsję u 56% kobiet z f / t PSA <0 8="" ale="" f="" przy="" psa="" t="" tylko=""> 0,25 ng / ml [ </0></span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_83" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">83</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Wolne / całkowity PSA nie ma zastosowania klinicznego, jeżeli łączna PSA w surowicy wynosi> 10 ng / ml lub w trakcie kontynuacji znanego PCA.</span></span></div>
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<span style="margin: 0px; padding: 0px;">Wolny / całkowitego PSA należy stosować ostrożnie, ponieważ może to mieć negatywny wpływ kilka czynników wstępnej analizy i klinicznych (na przykład, chwiejność wolnego PSA w temperaturze 4 ° C i temperaturą pokojową, zmienne Charakterystyka testu i jednoczesne BPH dużych prostaty) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_84" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">84</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_2_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">. 5.2.2.4</span></span><span style="margin: 0px; padding: 0px;"> Dodatkowe badania surowicy</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Kilka testów pomiarowych panel kallikreiny w surowicy lub osoczu krwi są obecnie dostępne w handlu, w tym FDA prostaty Indeks Zdrowia (fi) testu łączenia wolnego i całkowitego PSA i (-2) izoformy pro-PSA (p2PSA) i cztery kalikreiny (4K) wynik testu (pomiar wolnego, nienaruszone i całkowitego PSA oraz kalikreina-Like peptydazy 2 [HK2]), oba testy mają na celu zmniejszenie liczby niepotrzebnych biopsji prostaty u mężczyzn PSA testowane. </span><span style="margin: 0px; padding: 0px;">Kilka potencjalnych wieloośrodkowych badaniach wykazano, że zarówno PHI i 4k testowa-przeprowadzić f / t PSA PCa wykrywania, a poprawę przewidywania znaczącego klinicznie PCA wśród mężczyzn z PSA od 2-10 ng / ml [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_85" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">85</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_86" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">86</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<a href="https://www.blogger.com/null" name="5_2_2_5" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.2.5.</span></span><span style="margin: 0px; padding: 0px;"> Marker PCA3</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">PCA3 to, niekodujących biomarkera mRNA specyficznego dla prostaty, który jest wykrywalny w moczu osadów otrzymanych po trzech uderzeń masażu stercza podczas DRE. </span><span style="margin: 0px; padding: 0px;">Dostępny w handlu badanie moczu Progensa dla PCA3 jest lepszy procent całkowitego i wolnego od PSA do wykrywania PCa u mężczyzn z podwyższonym PSA, ponieważ pokazuje znaczące zwiększenie powierzchni pod odbiornik operatora krzywej charakterystycznej dla dodatnich biopsji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_87-90" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">87-90</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">PCA3 wynik wzrasta wraz z objętością PCA, ale istnieją sprzeczne dane na temat tego, czy niezależnie przewiduje Gleasona, a jego stosowanie przy kontroli aktywnego nadzoru (AS) jest niepotwierdzone [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_91" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">91</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Obecnie głównym wskazaniem do badania Progensa jest ustalenie, czy należy powtórzyć biopsji jest potrzebne po początkowym wynikiem ujemnym biopsji, ale jej skuteczności klinicznej dla tego celu jest niepewne [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_92" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">92</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<a href="https://www.blogger.com/null" name="5_2_2_6" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.2.6.</span></span><span style="margin: 0px; padding: 0px;"> Wytyczne do oceny ryzyka bezobjawowych mężczyzn</span></h4>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zalecenie</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Oferta dalszej oceny ryzyka dla bezobjawowych mężczyzn z PSA pomiędzy 2-10 ng / ml przed wykonaniem biopsji prostaty. </span><span style="margin: 0px; padding: 0px;">Użyj jednego z następujących narzędzi:</span></span></div>
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<span style="margin: 0px; padding: 0px;">• Ryzyko Kalkulator;</span></div>
<div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">• dodatkowy surowicy lub moczu na bazie testu (np PHI, 4Kscore lub PCA3) lub obrazowanie.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">do</span></div>
</td></tr>
</tbody></table>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">PSA = antygen gruczołu krokowego; </span><span style="margin: 0px; padding: 0px;">PHI = test prostaty Indeks Zdrowia.</span></span></div>
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<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.3.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Prostaty Biopsja</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.1.</span></span><span style="margin: 0px; padding: 0px;"> Baseline biopsji</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Konieczność biopsji stercza opiera się na poziom PSA i / lub podejrzanej DRE. </span><span style="margin: 0px; padding: 0px;">Wiek, potencjał schorzeń współistniejących i terapeutyczne konsekwencje powinny być również uwzględnione i omówione wcześniej [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_93" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">93</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Stratyfikacja ryzyka jest potencjalnym narzędziem zmniejszenia zbędnych biopsji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_93" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">93</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Elewacja z ograniczoną PSA sama w sobie nie powinna skłaniać do natychmiastowego biopsję. </span><span style="margin: 0px; padding: 0px;">Poziom PSA powinny być zweryfikowane po kilku tygodniach przy użyciu tego samego testu w standardowych warunkach (tj, bez wytrysku, manipulacji i infekcje dróg moczowych), w tym samym laboratorium [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_94" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">94</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_95" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">95</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Empiryczne stosowanie antybiotyków u pacjentów bez objawów, w celu zmniejszenia PSA, nie powinny być podejmowane [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_96" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">96</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Ultradźwięki (US) -guided biopsji jest obecnie standardem leczenia. </span><span style="margin: 0px; padding: 0px;">Podejście transrectal służy do większości biopsji prostaty, chociaż niektórzy urolodzy wolą krocza podejścia. </span><span style="margin: 0px; padding: 0px;">Współczynniki wykrywania raka są porównywalne z obu metod [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_97" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">97</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_98" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">98</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<a href="https://www.blogger.com/null" name="5_2_3_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.2.</span></span><span style="margin: 0px; padding: 0px;"> Powtórz po biopsji wcześniej negatywnej biopsji</span></h4>
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<span style="margin: 0px; padding: 0px;">Wskazania do biopsji powtórzyć to:</span></div>
<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">rośnie i / lub stale podwyższone PSA (patrz tabela 5.2 oszacowań ryzyka);</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">podejrzane DRE, 5-30% ryzyko raka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_67" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">67</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_68" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">68</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">atypowy rozrost małe groniastych (czyli nietypowe gruczoły podejrzanych o raka), 40% ryzyka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_99" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">99</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">rozległe (wiele witryn biopsji, tj  </span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;">  3) wysokiej klasy prostaty nowotwory śródnadbłonkowe (HGPIN),  </span><span class="Glyph" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">~</span></span><span style="margin: 0px; padding: 0px;">30% ryzyka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_99" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">99</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_100" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">100</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">kilka nietypowych gruczoły bezpośrednio przylegające do wysokiej jakości śródnabłonkowej neoplazji stercza  </span><br style="-webkit-font-smoothing: antialiased; box-sizing: border-box; margin: 0px; padding: 0px;" /><span style="margin: 0px; padding: 0px;">(tj PINATYP)  </span><span class="Glyph" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">~</span></span><span style="margin: 0px; padding: 0px;"> 50% ryzyka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_101" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">101</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">wewnątrzprzewodowego raka jako samotnego stwierdzenia,> 90% ryzyko raka stowarzyszonych wysokiej jakości prostaty [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_102" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">102</span></a><span style="margin: 0px; padding: 0px;"> ];</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Pozytywne multiparametric ustalenia MRI (patrz punkt 5.2.4).</span></li>
</ul>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Dodatkowe informacje można uzyskać na podstawie testu Progensa DRE moczu PCA3 test 4K oraz PHI surowicy lub epigenetycznego testu na bazie tkanek (ConfirmMDx). </span><span style="margin: 0px; padding: 0px;">Rola PHI i Progensa PCA3 w podejmowaniu decyzji, czy podjąć powtórzyć biopsję u mężczyzn, którzy mieli poprzednią negatywną biopsji jest niepewny i prawdopodobnie nieopłacalne [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_92" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">92</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Test ConfirmMDx opiera się na koncepcji, że łagodny przerost tkanki w sąsiedztwie PCa naciskiem wykazuje wyraźnych zmian epigenetycznych. </span><span style="margin: 0px; padding: 0px;">Jeżeli, ze względu na próbkowanie nastawienie, PCA pominięcia przy biopsji, demonstracja epigenetyczne zmiany w sąsiedniej tkanki łagodnego wskazywałoby na obecność raka. </span><span style="margin: 0px; padding: 0px;">Test ConfirmMDX ilościowo poziom metylacji regionów promotora trzech genów (RASSF1, GSTP1 i APC) w tkance gruczołu krokowego łagodny. </span><span style="margin: 0px; padding: 0px;">Niedawne badanie wieloośrodkowe stwierdzono ujemną wartość predykcyjną 88%, gdy metylacja był nieobecny we wszystkich trzech markerów, co oznacza, że należy powtórzyć biopsję można uniknąć tych ludzi [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_103" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">103</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Ze względu na ograniczoną obecnie dostępne dane, brak zaleceń może być wykonana w odniesieniu do jego rutynowego stosowania.</span></span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.3.2 Opis dodatkowych testów badanych po negatywnej biopsji prostaty *</span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nazwa testu</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Badany substrat</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Molekularny</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">zatwierdzony przez FDA</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Progensa</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">DRE moczu</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">lncRNA PCA3</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">tak</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">PHI</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Serum</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Razem, wolny i p2PSA</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">tak</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">4Kscore test</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Surowicy / osocza</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
Total, free, intact PSA, hK2</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ConfirmMDX</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Łagodny rozrost gruczołu krokowego biopsja</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Metylowane APC, RASSF1 i GSTP1</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie</span></div>
</td></tr>
</tbody></table>
<div class="bodytekst_italic_onder_tabel 1e regel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">* Pojedyncze PIN wysokiej jakości w jednym lub dwóch miejscach biopsji nie jest wskazaniem do powtórzenia biopsji [</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_104" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">104</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.3.</span></span><span style="margin: 0px; padding: 0px;"> Nasycenie biopsji</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Częstość powtarzania PCa wykrywane przez nasycenie biopsji (> 20 rdzeni) jest 30-43% i zależy od ilości rdzeni próbą w poprzednich biopsji [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_105" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">105</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Nasycenie biopsji może być wykonane z zastosowaniem techniki transperineal, który wykrywa dodatkowy 38% PCA. </span><span style="margin: 0px; padding: 0px;">Wysokie tempo zatrzymania moczu (10%) jest wadą [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_106" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">106</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.4.</span></span><span style="margin: 0px; padding: 0px;"> Miejsc pobierania próbek oraz liczba rdzeni</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Na bazowych biopsji, strony próbek powinny być dwustronne od wierzchołka do podstawy, na ile tylnej i bocznych, jak to możliwe w gruczole obwodowej. </span><span style="margin: 0px; padding: 0px;">Dodatkowe rdzenie powinny być uzyskane z podejrzanych obszarów dre / TRUS.</span><span style="margin: 0px; padding: 0px;">Sekstant biopsji nie jest już uważane za wystarczające. </span><span style="margin: 0px; padding: 0px;">Dla objętości prostaty o 30-40 ml,  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">  8 rdzeni należy pobrać próbki. </span><span style="margin: 0px; padding: 0px;">Dziesięć do 12 rdzeniowe biopsje zaleca się [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_107" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">107</span></a><span style="margin: 0px; padding: 0px;"> ], a> 12 rdzenie nie są znacznie bardziej jednoznaczne [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_108" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">108</span></a><span style="margin: 0px; padding: 0px;"> ,</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_109" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">109</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_5" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.5.</span></span><span style="margin: 0px; padding: 0px;"> Diagnostic przezcewkowej resekcji gruczołu krokowego</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Przezcewkowa prostaty nie powinny być stosowane jako narzędzie do wykrywania raka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_110" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">110</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_6" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.6.</span></span><span style="margin: 0px; padding: 0px;"> Pęcherzyk nasienny biopsji</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Wskazania do pęcherzyków nasiennych (postoju) biopsji są słabo zdefiniowane. </span><span style="margin: 0px; padding: 0px;">Na PSA> 15 ng / ml, szanse na zaangażowanie guza są 20-25% [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_111" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">111</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Pęcherzyk nasienny inscenizacja biopsji jest przydatna tylko jeśli ma decydujący wpływ na leczenie, na przykład wykluczając radykalnej resekcji guza lub potencjalnego kolejnego radioterapii. </span><span style="margin: 0px; padding: 0px;">Jego wartość dodaną w porównaniu z multiparametric rezonans magnetyczny (mpMRI) jest wątpliwa.</span></span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_7" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.7.</span></span><span style="margin: 0px; padding: 0px;"> Biopsja strefy przejściowej</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Próbkowania strefę przejściową podczas wyjściowej biopsji ma niski poziom wykrywania, powinna być ograniczona, aby powtórzyć biopsje [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_112" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">112</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_8" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.8.</span></span><span style="margin: 0px; padding: 0px;"> Antybiotyki przed biopsją</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Zaleca się doustnie lub dożylnie antybiotyki. </span><span style="margin: 0px; padding: 0px;">Chinolony są lekami z wyboru, z cyprofloksacyny jest lepsza ofloksacyny [</span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_113" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">113</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Zwiększona odporność na chinolony [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_114" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">114</span></a><span style="margin: 0px; padding: 0px;"> ], jest związana ze wzrostem poważnych infekcji po biopsji [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_115" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">115</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_9" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.9.</span></span><span style="margin: 0px; padding: 0px;"> Znieczulenie miejscowe przed biopsją</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">USG okołosterczowej bloku jest zalecane [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_116" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">116</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Nie jest ważne, czy zajezdnia jest koniuszka lub podstawnokomórkowego. </span><span style="margin: 0px; padding: 0px;">Doodbytniczo wkraplanie znieczuleniu miejscowym jest gorsza okołosterczowej infiltracji [</span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_117" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">117</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_10" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.10.</span></span><span style="margin: 0px; padding: 0px;"> Precyzyjna igła aspiracyjna cienkoigłowa</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie zaleca się już w porządku-igłowa biopsja aspiracyjna.</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_3_11" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.3.11.</span></span><span style="margin: 0px; padding: 0px;"> Komplikacje</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Powikłania biopsji są wymienione w tabeli 5.2.2 [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_118" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">118</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Ciężkie zakażenia po zabiegach były początkowo u <1 ale="" antybiotyki="" ci="" font="" na="" nbsp="" oporno="" przypadk="" w="" wyniku="" wzros="" y=""></1></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_119" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">119</span></a><span style="margin: 0px; padding: 0px;"> ].</span></span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Niskie dawki aspiryny nie jest bezwzględnym przeciwwskazaniem [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_120" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">120</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.2: procent komplikacji podczas sesji biopsji, bez względu na liczbę rdzeni</span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">komplikacje</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Odsetek pacjentów dotkniętych</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">hematospermia</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
37.4</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Krwiomocz> 1 dzień</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
14.5</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Krwawienie z odbytu <2 dni="" font=""></2></span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
2.2</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zapalenie gruczołu krokowego</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">1.0</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Gorączka> 38,5 ° C</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">0.8</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">najądrza</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.7</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Krwawienie z odbytnicy> 2 dni +/- interwencja chirurgiczna</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">0.7</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zatrzymanie moczu</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.2</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Inne powikłania wymagające hospitalizacji</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="50%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.3</div>
</td></tr>
</tbody></table>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.4.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Rola obrazowania</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_4_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.4.1.</span></span><span style="margin: 0px; padding: 0px;"> TRUS i technik opartych na US</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Szary skalę TRUS nie jest wiarygodny w wykrywaniu PCA [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_121" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">121</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Tak więc, nie ma dowodów na to, że amerykańskie ukierunkowane biopsje mogą zastąpić systematyczne biopsje. </span><span style="margin: 0px; padding: 0px;">Nowe ultrasonograficznych sposoby takie jak sonoelastography i kontrastem USA są obecnie badane. </span><span style="margin: 0px; padding: 0px;">Obecnie nie ma wystarczających dowodów na ich rutynowego stosowania [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_122" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">122</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_4_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.4.2.</span></span><span style="margin: 0px; padding: 0px;"> Multiparametric rezonans magnetyczny (mpMRI)</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Korelacja z radykalnej prostatektomii (RP) pokazuje, że mpMRI, kojarząc obrazowanie T2-ważony obrazowania dyfuzji ważony, dynamicznego obrazowania kontrastem i / lub H1-spektroskopii, posiada doskonałą czułość wykrywania i lokalizacji skali Gleasona  </span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;">  7 nowotworów ( patrz tabela 5.2.3) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_123-126" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">123-126</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.3: Wskaźniki PCA wykrywania (%) według mpMRI dla objętości guza i Gleasona  </span><span class="bodytekst" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">[ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_126" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">126</span></span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]</span></span></span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Gleasona</span></div>
</th><th class="Celstijl_1_tint_zwart" colspan="3" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="75%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Objętość guza (ml)</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"></td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><0 font=""></0></span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
0.5-2</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">> 2</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GS6</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
21-29%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
43-54%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
67-75%</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GS7</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
63%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
82-88%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
97%</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GS> 7</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
80%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
93%</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
100%</div>
</td></tr>
</tbody></table>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Wiele badań pojedynczych centrów sugerują, że mpMRI może niezawodnie wykrywać agresywnych nowotworów u kandydatów do biopsji prostaty z ujemną (NPV) oraz wartość predykcyjna wyniku dodatniego (PPV) w zakresie od 63 do 98% i od 34 do 68%, odpowiednio, [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_127" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">127</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Stowarzyszenie systematycznych biopsji oraz biopsji ukierunkowanych na nieprawidłowości mpMRI (MRI-TBX) może także lepiej przewidzieć ostateczny patologiczny stopień znaleźć na prostatektomii [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_128" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">128</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W rezultacie, niektóre wykonania zaproponowano mpMRI przed biopsji, aby zwiększyć detekcję agresywne nowotwory i zmniejszenie ponad wykrywanie nieistotnego ognisk [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_129-132" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">129-132</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Jednym z ostatnich metaanaliza potwierdziła, że u mężczyzn z nieprawidłowym mpMRI, MRI tbx miały wyższy wskaźnik wykrywalności klinicznie istotnego PCa w porównaniu do biopsji TRUS (czułość 0,91 [95% CI: 0.87-0.94] vs 0,76 [95 % CI: 0.64- 0.84]) oraz niższa stopa wykrywania nieznacznej PCa (czułość 0,44, 95% CI: 0.26-0.64 vs 0,83, 95% CI: 0.77-0.87). </span><span style="margin: 0px; padding: 0px;">Jednakże analiza podgrupa wykazały, że MRI tbx znacznie poprawia wykrywanie znacznym PCa w warunkach powtarzania biopsji (względem czułości 1,62 [95% CI: 1.02-2.57]), ale nie u mężczyzn z początkowym biopsji (współczynnik czułości 0,97 [ 95% przedział ufności: 0.94-1.01]) [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_133" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">133</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Kolejny przegląd systematyczny doszedł do podobnych wniosków [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_122" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">122</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Dwa ostatnie RCT nieuwzględnione w meta-analiz i występował u pacjentów poddanych wstępnej biopsji, przyniosły sprzeczne wyniki co do tego, czy stowarzyszenie systematycznych biopsji i MRI-TBX miały wyższy wskaźnik wykrywalności niż sam systematycznych biopsji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_134" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">134</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_135" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">135</span></a><span style="margin: 0px; padding: 0px;"> ] ,</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">To jest pewne, czy negatywna mpMRI może uzasadniać pomijając biopsji ze względu na różnorodność i możliwości wyboru nastawienia opublikowanych badań [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_122" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">122</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_127" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">127</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Nie jest zatem możliwe zalecamy stosowanie ukierunkowanych tylko biopsje [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_3" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">3</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Multiparametric MRI pozostaje ograniczona przez jego zmienności między czytnikiem a niejednorodności w definicji badań pozytywnych i negatywnych. </span><span style="margin: 0px; padding: 0px;">Pierwsza wersja prostaty Obrazowanie Sprawozdawczość i DataSystem (PIRADS) system punktacji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_136" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">136</span></a><span style="margin: 0px; padding: 0px;"> ] udało się poprawić interpretację inter-czytnika w porównaniu do subiektywnej gola [</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_137" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">137</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_138" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">138</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Uaktualniona wersja (PIRADS V2) został zaproponowany niedawno, ale musi być oceniana dalej [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_139" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">139</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_4_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.4.3.</span></span><span style="margin: 0px; padding: 0px;"> Wytyczne do obrazowania</span></h4>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zalecenie</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Przed powtórnym biopsji, wykonaj mpMRI gdy kliniczne podejrzenie PCa utrzymuje się pomimo negatywnych biopsji.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">1a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Podczas powtarzania biopsji obejmują systematyczne biopsje i kierowania jakichkolwiek zmian mpMRI widziałem.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
</tbody></table>
<div class="bodytekst_italic_onder_tabel 1e regel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mpMRI = multiparametric rezonansu magnetycznego.</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_5" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.5.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Patologia igieł biopsji prostaty</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_5_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.5.1.</span></span><span style="margin: 0px; padding: 0px;"> Tworzenie</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Biopsje prostaty rdzeniowe z różnych stron są przetwarzane oddzielnie. </span><span style="margin: 0px; padding: 0px;">Przed przetwarzaniem, ilość i długość rdzenia są rejestrowane. </span><span style="margin: 0px; padding: 0px;">Długość biopsji istotnie koreluje z wykrywalności PCa [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_140" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">140</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Aby osiągnąć optymalne spłaszczenie i wyrównanie, maksymalnie trzy rdzenie powinny być osadzone na kasecie tkanek i gąbki lub papier używany do utrzymania rdzeni rozciągnięte i płaskie [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_141" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">141</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_142" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">142</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W celu optymalizacji wykrywania niewielkich zmian, bloczki parafinowe należy wyciąć na trzech poziomach [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_112" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">112</span></a><span style="margin: 0px; padding: 0px;"> ] i interwencji niewybarwione sekcje są przechowywane przez immunohistochemię.</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_5_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.5.2.</span></span><span style="margin: 0px; padding: 0px;"> Mikroskopia i raportowanie</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Rozpoznanie PCA na podstawie analizy histologicznej. </span><span style="margin: 0px; padding: 0px;">Kryteria diagnostyczne obejmują cechy znamienne dla tej choroby raka, większych i mniejszych możliwości sprzyjających rakowi i możliwości w walce z rakiem. </span><span style="margin: 0px; padding: 0px;">Pomocnicze barwienie i dodatkowe sekcje (głębsze) należy rozważyć, czy podejrzany uszkodzenie jest identyfikowany [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_143-145" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">143-145</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Niepewność diagnostyczny został rozwiązany przez intradepartmental lub zewnętrznego konsultacji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_143" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">143</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Tabela 5.2.4 wymienia zalecanej terminologii za zgłoszenie biopsje prostaty [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_141" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">141</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Tabela 5.2.4: Zalecane terminy zgłaszania biopsje prostaty [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_141" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">141</span></a><span style="margin: 0px; padding: 0px;"> ]</span></div>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Łagodny / negatywne dla nowotworu. </span><span style="margin: 0px; padding: 0px;">W razie potrzeby, zawierać opis.</span></span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">aktywne zapalenie</span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ziarniniakowe zapalenie</span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">PIN wysokiej jakości</span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">PIN wysokiej jakości z nietypowymi gruczołów, podejrzanych o raka gruczołowego (PINATYP)</span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Skupienie nietypowej gruczoły / zmiany podejrzane dla gruczolakoraka / nietypowej małej proliferacji groniastej, podejrzanych o raka</span></div>
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<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">gruczolakorak</span></div>
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<span style="margin: 0px; padding: 0px;">rakiem wewnątrzprzewodowym</span></div>
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<span style="margin: 0px; padding: 0px;">PIN = nowotwory śródnadbłonkowe prostaty.</span></div>
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<span style="margin: 0px; padding: 0px;">Każda witryna biopsji powinny być zgłaszane indywidualnie, w tym jego adres (zgodnie z miejscem pobierania próbek) i histopatologicznych, które obejmują typ histologiczny i wynik ISUP 2005 Gleason (czyli 2005 ISUP Modified Gleason System) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_31" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">31</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Globalna Gleasona obejmujący wszystkie biopsje Doniesiono również, jak również grupy zaszeregowania ISUP 2014 (patrz punkt 4.2). </span><span style="margin: 0px; padding: 0px;">Wewnątrzprzewodowego rak, inwazja naczyń chłonnych i extraprostatic rozszerzenie musi każdy, o ile są identyfikowane.</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Odsetek rdzeniami raka-dodatnie, jak i stopień zaangażowania guza na rdzeń biopsji koreluje z Gleasona, wielkość guza, marginesów chirurgicznych i patologicznego etapie okazów RP i przewiduje BCR, po prostatektomii progresji i niewydolność RT. </span><span style="margin: 0px; padding: 0px;">Te parametry są zawarte w nomogramów utworzonych przewidzieć patologiczną scenę i nasienny inwazję pęcherzyka po RP i niewydolności RT [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_146-148" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">146-148</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Raport patologia powinna zatem stanowić zarówno część rdzeni raka-dodatnich i zakres zaangażowania raka dla każdego rdzenia. </span><span style="margin: 0px; padding: 0px;">Długość w mm oraz odsetek raka w biopsji mają jednakowy wpływ prognostyczną [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_149" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">149</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Rozległe> 50% gruczolakoraka w pojedynczym rdzeniem jest stosowany w niektórych jako protokołów jako odcięcia [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_150" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">150</span></a><span style="margin: 0px; padding: 0px;"> ] wyzwalania natychmiastowego leczenia vs. AS u pacjentów ze skali Gleasona 6.</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Biopsja prostaty, który nie zawiera tkanki gruczołowej powinny być zgłaszane jako diagnostycznie niewystarczające. </span><span style="margin: 0px; padding: 0px;">Obowiązkowe elementy mają być zgłoszone do biopsji prostaty rak-dodatnie:</span></span></div>
<ul style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; list-style-position: outside; margin: 0px 0px 20px; outline: 0px; padding: 0px 18px; vertical-align: baseline;">
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">rodzaj raka</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">pierwotny i wtórny / najgorszego gatunku Gleason (na miejscu biopsji i globalna);</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Rak procent wysokiej jakości (globalna);</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">Zakres raka (w mm lub procentowo) (co najmniej jedno miejsce biopsji);</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">jeśli występuje: extraprostatic rozszerzenie, pęcherzyk nasienny inwazji, chłonnych inwazja, wewnątrzprzewodowego rak, inwazja peri-nerwowa;</span></li>
<li style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 0px 60px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">ISUP 2014 grupa ocena (globalna).</span></li>
</ul>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_5_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.5.3.</span></span><span style="margin: 0px; padding: 0px;"> Prognostyczna badania biomarkerów opartych Tissue</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Test Prolaris (Myriad Genetics) mierzy ekspresję 31 cyklu komórkowego związanych genów pochodzących z biopsji tkanki PCa i może mieć zastosowanie kliniczne w celu ustalenia, czy pacjent potrzebuje leczenia leczniczo lub mogą być jego leczenie odroczone [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_151" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">151</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Podobnie Oncotype dx test RNA opartego o 12 genów związanych z rakiem i 5 genów referencyjnych, które można zastosować do tkanki raka prostaty, w biopsji określić agresywności nowotworu.</span><span style="margin: 0px; padding: 0px;">Oba testy zostały wykazane w badaniach prospektywnych dostarczenie informacji prognostycznych u mężczyzn z rozpoznaniem klinicznym PCA dodatkowe do konwencjonalnych parametrów kliniczno-patologicznych, w tym Gleasona oraz poziomu PSA. </span><span style="margin: 0px; padding: 0px;">Wyniki wieloośrodkowych prospektywnych badań oczekiwane są przed mogą być wykonane zalecenie dotyczące ich rutynowego stosowania.</span></span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_6" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.6.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Badanie histopatologiczne preparatów prostatektomii radykalnej</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.1.</span></span><span style="margin: 0px; padding: 0px;"> Przetwarzanie radykalnej prostatektomii okazów</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Badanie histopatologiczne preparatów RP opisuje patologiczny etap, histopatologicznej rodzaj, stopień i marginesów chirurgicznych PCA. </span><span style="margin: 0px; padding: 0px;">Zaleca się, że próbki RP są całkowicie osadzone w celu umożliwienia oceny lokalizacji nowotworów, wieloogniskowość i niejednorodności. </span><span style="margin: 0px; padding: 0px;">Dla opłacalności, częściowe osadzanie może również uznać, zwłaszcza dla prostaty> 60 g. </span><span style="margin: 0px; padding: 0px;">Najbardziej powszechnie przyjętą metodą obejmuje kompletny osadzanie prostaty tylnej, a pojedynczy połowie przednio lewy i prawy punkt. </span><span style="margin: 0px; padding: 0px;">W porównaniu z całkowitą wbudowania, częściowe osadzanie wykryto 98% PCA z Gleasona  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">></span></span><span style="margin: 0px; padding: 0px;">  7 i dokładnego inscenizacji w 96% przypadków [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_152" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">152</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Tusz cała próbka RP po otrzymaniu w laboratorium, w celu wykazania marginesów chirurgicznych. </span><span style="margin: 0px; padding: 0px;">Próbki są mocowane przez zanurzenie w buforowanej formalinie przez co najmniej 24 godzin, korzystnie przed krojenia.</span><span style="margin: 0px; padding: 0px;">Zamocowanie można zwiększyć przez iniekcję formaliny, która zapewnia bardziej jednorodny mocowania i cięcia po 24 godzinach [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_153" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">153</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Po utrwaleniu, wierzchołek i podstawa (szyi pęcherza) usunięto i pocięto (para) lub promieniowych sekcji strzałkowej; </span><span style="margin: 0px; padding: 0px;">Sposób golenia nie jest zalecane [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_31" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">31</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Pozostała część próbki są cięte w kierunku poprzecznym, rozdziały 3-4 mm, w kierunku prostopadłym do wzdłużnej osi cewki. </span><span style="margin: 0px; padding: 0px;">Powstałe plastry tkanki mogą być osadzone i przetwarzane w całych mocowań lub po kwadrancie cięcia. </span><span style="margin: 0px; padding: 0px;">Whole-wierzchowce zapewniają lepszą wizualizację topograficzną, badanie histopatologiczne szybciej i lepszej korelacji z obrazowaniem przedoperacyjnej, choć są one bardziej czasochłonne i wymagają specjalnego traktowania. </span><span style="margin: 0px; padding: 0px;">Do rutynowych skrawków, zalety całych mocowań nie przewyższają ich wady.</span></span></div>
<h5 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_1_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.1.1.</span></span><span style="margin: 0px; padding: 0px;"> Wytyczne dotyczące przetwarzania próbek prostatektomii</span></h5>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zalecenie</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zapewnić całkowite osadzanie, przez konwencjonalne (ćwiartki) lub cały zamontować cięcia.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">do</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tusz cała powierzchnia przed cięciem, w celu oceny marginesu chirurgicznego.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zbadać wierzchołek i podstawę oddzielnie metodą stożka z strzałkowej lub promieniowej cięcia.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
</tbody></table>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.2.</span></span><span style="margin: 0px; padding: 0px;"> RP Wzór sprawozdania</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Raport patologia dostarcza istotnych informacji na temat cech prognostycznych istotnych dla podejmowania decyzji klinicznych (tabela 5.2.5). </span><span style="margin: 0px; padding: 0px;">W wyniku skomplikowanej informacji umieszczonych na każdej próbce RP stosowanie synoptyczne (-podobnych) lub raportowania Lista ta zalecana (Tabela 5.2.6). </span><span style="margin: 0px; padding: 0px;">Synoptyczne Wyniki raportowania w bardziej przejrzystej i kompletnej sprawozdawczości patologii [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_154" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">154</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.5: Elementy obowiązkowe podane w raporcie patologii</span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Typ histopatologiczne:> 95% PCA reprezentuje tradycyjne (groniastych) gruczolakoraka.</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Klasyfikacji według Gleasona (lub zmian związanych z leczeniem) i ISUP 2014 grupy zaszeregowania.</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nowotwór (sub) rusztowania i chirurgiczne stanu marginesu: lokalizacja i zakres extraprostatic rozszerzeniu obecność inwazji szyi pęcherza, lateralizacją extraprostatic rozbudowy lub nasiennego inwazji pęcherzyku, umiejscowienia i rozległości dodatnich marginesów chirurgicznych.</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Dodatkowe informacje mogą znajdować się na wieloogniskowość i średnicy / objętość i strefowego położenia dominującej guza.</span></div>
</td></tr>
</tbody></table>
<div class="bodytekst_bold" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Tabela 5.2.6 Przykład: Lista kontrolna: raportowanie okazów prostatektomii</span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Typ histopatologiczne</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">• Typ raka, np konwencjonalna pęcherzykowych lub przewodowy</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">stopniem złośliwości histologicznej</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Pierwotne (przeważającym) klasy</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">wtórna klasa</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Szkolnictwo ocena (jeśli dotyczy)</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Globalny Gleason score / ISUP 2014 Grupa grade</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Przybliżony procentowy stopień Gleasona 4 lub 5</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nowotwór ilościowe (opcjonalnie)</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Procentowy udział prostaty</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Rozmiar / Objętość guza dominującej guzka</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Patologiczny postoju (pTNM)</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstitalic_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: italic; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Jeśli extraprostatic rozszerzenie występuje:</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">wskazać, czy jest ogniskowa lub rozległa</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">określić witryny</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Należy wskazać, czy jest pęcherzyk nasienny inwazja</span></div>
<div class="tabel_bodytekstitalic_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: italic; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">W stosownych przypadkach, regionalnych węzłów chłonnych:</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Lokalizacja</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">liczba węzłów pobierane</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Liczba węzłów zaangażowanych</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_8pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">marginesy chirurgiczne</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstitalic_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: italic; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Jeśli rakiem występuje na brzegu:</span></div>
<div class="tabel_bodytekst_9pt_open bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">określić witryny</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Inny</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="100%"><div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Obecność chłonnych / angio-inwazji</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Umiejscowienie guza dominującej</span></div>
<div class="tabel_bodytekst_9pt_bullet" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px 30px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Występowanie raka wewnątrzprzewodowym</span></div>
</td></tr>
</tbody></table>
<h5 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_2_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.2.1.</span></span><span style="margin: 0px; padding: 0px;"> Gleasona w próbkach prostatektomii</span></h5>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Klasyfikację konwencjonalnej raka gruczołu krokowego przy użyciu zmodyfikowanego (ISUP 2005) Układ Gleason [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_31" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">31</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] jest najsilniejszym czynnikiem prognostycznym dla zachowania klinicznej i odpowiedzi na leczenie. </span><span style="margin: 0px; padding: 0px;">Wynik Gleason jest włączone nomogramów które przewidują przeżycie swoiste dla choroby po prostatektomii [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_155" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">155</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Wynik Gleason jest sumą najbardziej i drugiego najbardziej dominującej (w ujęciu ilościowym) stopień Gleasona. </span><span style="margin: 0px; padding: 0px;">Jeśli tylko jeden gatunek jest obecny, główny gatunek jest podwojona. </span><span style="margin: 0px; padding: 0px;">Jeśli gatunek obejmuje  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><</span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">  5% objętości nowotworu nie jest włączona do Gleasona (5% reguły). </span><span style="margin: 0px; padding: 0px;">Gatunki pierwotne i wtórne są podawane w dodatku do Gleasona. </span><span style="margin: 0px; padding: 0px;">Globalna Gleasona jest podana dla wielu nowotworów, ale oddzielny ostrości guza z wyższym Gleasona należy również wymienić. </span><span style="margin: 0px; padding: 0px;">Szkolnictwo stopnia Gleasona 4 lub 5, w szczególności, jeżeli> 5% objętości PCA jest niekorzystny wskaźnik prognostyczny BCR. </span><span style="margin: 0px; padding: 0px;">Trzeciorzędowa grade a jego przybliżona proporcja objętości nowotworu powinny również zostać zgłoszone [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_156" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">156</span></a><span style="margin: 0px; padding: 0px;"> ] w uzupełnieniu do globalnej skali Gleasona oraz grupy zaszeregowania ISUP 2014 (patrz punkt 4.2).</span></div>
<h5 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_2_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.2.2.</span></span><span style="margin: 0px; padding: 0px;"> Definicja extraprostatic rozszerzeniem</span></h5>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Extraprostatic rozszerzenie definiuje się jako rak mieszany z okołosterczowej tkanki tłuszczowej lub tkanki, która wykracza poza granice gruczołu krokowego (np naczyniową wiązki, przednia prostaty). </span><span style="margin: 0px; padding: 0px;">Mikroskopijne inwazja szyi pęcherza moczowego jest uważany extraprostatic rozszerzenie. </span><span style="margin: 0px; padding: 0px;">Warto zgłosić lokalizację i zakres extraprostatic przedłużenia, ponieważ jest ona związana z ryzykiem nawrotu [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_157" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">157</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Nie ma już uznanych międzynarodowo definicje ogniskowej lub mikroskopowym vs. pobocznych lub rozległe rozszerzenie extraprostatic. </span><span style="margin: 0px; padding: 0px;">Niektóre opisuje ogniskową, jak kilka dławików [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_158" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">158</span></a><span style="margin: 0px; padding: 0px;"> ] lub rozciągnięcie <1 font="" mocy="" nbsp="" o="" pola="" wysokiej=""><a href="https://uroweb.org/guideline/prostate-cancer/#note_159" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">159</span></a><span style="margin: 0px; padding: 0px;"> ], podczas gdy inne pomiaru głębokości stopnia w milimetrach [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_160" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">160</span></a><span style="margin: 0px; padding: 0px;"> ].</span></1></span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Na wierzchołku prostaty, guz mieszany z mięśni szkieletowych nie stanowią extraprostatic rozszerzenie. </span><span style="margin: 0px; padding: 0px;">W szyi pęcherza, mikroskopowe inwazja gładkich włókien mięśniowych nie jest przyrównywana do ściany inwazji pęcherza, to znaczy nie jako PT4, ponieważ nie prowadzi niezależne znaczenie prognostyczne dla PCa nawrotów [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_161" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">161</span></a><span style="margin: 0px; padding: 0px;">, </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_162" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">162</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] i powinny być rejestrowane jako extraprostatic przedłużacza (pT3a ). </span><span style="margin: 0px; padding: 0px;">Dodatni margines na szyi pęcherza powinny być zgłaszane jako rozszerzenie extraprostatic (pT3a) z dodatnim marginesem, a nie jako PT4.</span></span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Etap pT4 przypisany jest tylko wtedy, gdy guz nacieka ścianę mięśni pęcherza określona makroskopowo [</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_163" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">163</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.3.</span></span><span style="margin: 0px; padding: 0px;"> Objętość PCa</span></h4>
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<span style="margin: 0px; padding: 0px;">Niezależny Wartość prognostyczna objętości PCa w próbkach RP nie zostało ustalone [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_159" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">159</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_164-167" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">164-167</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Niemniej jednak odcięcia 0,5 ml jest powszechnie stosowany do odróżnienia nieistotne klinicznie istotnych raka [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_164" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">164</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Poprawa gruczołu radiowego obrazowania pozwala na dokładniejszy pomiar przedoperacyjną objętości nowotworu. </span><span style="margin: 0px; padding: 0px;">Zaleca się, aby co najmniej średnica / objętość guza dominującej guzka należy ocenić, czy oszacowanie odsetka tkanki nowotworowej do dyspozycji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_168" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">168</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_2_6_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.2.6.4.</span></span><span style="margin: 0px; padding: 0px;"> Chirurgiczne stanu marginesu</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Margines chirurgiczny jest niezależnym czynnikiem ryzyka BCR. </span><span style="margin: 0px; padding: 0px;">Stan graniczna jest dodatni, jeśli komórki rakowe są w kontakcie z tuszem na powierzchni próbki. </span><span style="margin: 0px; padding: 0px;">Stan graniczna jest ujemny, jeśli komórki rakowe są w pobliżu powierzchni tuszem [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_165" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">165</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ] lub na powierzchnię tusz tkanki brakuje. </span><span style="margin: 0px; padding: 0px;">W tkankach, które mają poważne artefakty zgniatać, to może nie być możliwe do określenia stanu marginesu [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_169" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">169</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Margines chirurgiczny jest niezależny od patologicznego etapie, a dodatni margines nie jest dowodem extraprostatic rozszerzenia [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_170" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">170</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Nie ma wystarczających dowodów na związek pomiędzy graniczną zakresu i ryzyka nawrotów [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_159" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">159</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Jednak pewne wskazanie musi być podany w zakresie wieloogniskowość margines dodatnich, takich jak liniowy stopniu mm udział: kontaktowych,  </span></span><span class="< > onderlijnen" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; text-decoration: underline; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><</span></span><span style="margin: 0px; padding: 0px;">  1 mm w porównaniu rozległej> 1 mm, [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_171" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">171</span></a><span style="margin: 0px; padding: 0px;"> ], lub liczbę bloków z dodatnim udział granicznej.</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_2_7" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.2.7.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Wytyczne dotyczące diagnostyki klinicznej PCA</span></span></span></h3>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zalecenie</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie używaj przezcewkowej resekcji prostaty jako narzędzie do wykrywania raka.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Użyj ISUP 2005 zmodyfikowaną System Gleasona klasyfikacji PCA.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Oprzeć decyzję, aby wykonać biopsję na badania PSA i DRE.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Użyć dodatkowych opcji diagnostycznych bezobjawowych mężczyzn z prawidłowym DRE i PSA pomiędzy 2,0 a 10 ng / ml (kalkulator ryzyka lub dodatkowego badania surowicy lub moczu oparte [np PHI, 4Kscore lub PCA3] lub obrazowania).</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">do</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie początkowo oferowane biopsje strefa przejściowa z powodu niskich stóp wykrywania.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Do wstępnej diagnozy, należy wykonać biopsję rdzeniową 10-12 systematycznego podawania doodbytniczego lub transperineal strefie peryferyjnej biopsje pod kontrolą USG.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Wykonaj transrectal biopsje prostaty igieł pod ochroną antybiotykami.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">1b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Użyj znieczulenie miejscowe przez okołosterczowej infiltracji dla biopsji igłowych prostaty.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">1a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Upewnić się, że podstawowa biopsje prostaty z różnych stron są przekazywane odrębnie dla raportów przetwarzania i patologia.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Przylegają do 2010 ISUP wytycznych spotkań zgoda na przetwarzanie i raportowanie okazów prostatektomii.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">3</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Wykonaj jeden zestaw powtarzających biopsji do trwałych oznaczeń na PCa (nieprawidłowe DRE, podwyższone PSA lub histopatologicznych sugerującymi złośliwości przy początkowym biopsja).</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">b</span></div>
</td></tr>
</tbody></table>
<div class="bodytekst_italic_onder_tabel 1e regel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">DRE = badanie per rectum; </span><span style="margin: 0px; padding: 0px;">ISUP = Międzynarodowe Towarzystwo Urologicznego Patologii; </span><span style="margin: 0px; padding: 0px;">PCa = raka prostaty;</span></span></div>
<div class="bodytekst_italic_onder_tabel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">PCA3 = gen raka prostaty 3; </span><span style="margin: 0px; padding: 0px;">PHI = prostaty Indeks Zdrowia; </span><span style="margin: 0px; padding: 0px;">PSA = swoistego antygenu sterczowego.</span></span></div>
<h2 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 17px; font-stretch: inherit; font-weight: 500; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span style="border: 0px; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">. 5,3</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Diagnoza: Inscenizacja kliniczna</span></span></span></h2>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Zakres PCa oceniano przez DRE i PSA, i może być uzupełniony skanowania kości i CT lub mpMRI.</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.3.1.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> T-staging</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_1_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.1.1.</span></span><span style="margin: 0px; padding: 0px;"> Definicje</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Extraprostatic przedłużenie jest zdefiniowany jak rak mieszany z okołosterczowej tkanki tłuszczowej i tkanki, która rozciąga się poza gruczoł prostaty (np wiązki nerwowo-naczyniowe, przednia prostata lub szyi pęcherza moczowego) oraz odpowiadającego etapu T3a. </span><span style="margin: 0px; padding: 0px;">Należy odróżnić od inwazji pęcherzyka nasiennego (SVI), który odpowiada scenie T3B (patrz punkt 5.2 szczegółów).</span></span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_1_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.1.2.</span></span><span style="margin: 0px; padding: 0px;"> DRE, poziom PSA oraz biopsji ustalenia</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Pierwszy poziom oceny jest lokalny stadium nowotworu, ponieważ rozróżnienie między (T3 / T4) choroby narządów-ograniczone (T1 / T2) oraz extraprostatic wpływa na decyzje dotyczące leczenia. </span><span style="margin: 0px; padding: 0px;">DRE jest dodatnio skorelowana ze stadium nowotworu u <50 font="" nbsp="" przypadk="" w=""></50></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_172" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">172</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ], choć często nie docenia rozszerzenie guza. </span><span style="margin: 0px; padding: 0px;">Bardziej obszerne T-staging jest zalecane tylko wtedy, gdy ma bezpośredni wpływ na decyzje dotyczące leczenia.</span></span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">PSA w surowicy stężenie zwiększa się wraz ze stopniem zaawansowania klinicznego, choć są one ograniczone do dokładnego przewidywania końcowej fazie patologicznej. </span><span style="margin: 0px; padding: 0px;">Antygenu specyficznego dla prostaty jest produkowany przez tkankę łagodnych i złośliwych, a zatem nie ma bezpośredniego związku pomiędzy PSA w surowicy i kliniczno stadium nowotworu [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_173" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">173</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Biopsji gruczołu krokowego, procent tkanki nowotworowej jest silnym czynnikiem dodatnich marginesów chirurgicznych SVI, choroby narządu nie ogranicza [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_174" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">174</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Wzrost biopsji guza-dodatnich jest niezależnym predyktorem extraprostatic rozszerzeniem, udział marży i węzłów chłonnych inwazji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_175" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">175</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Serum PSA, Gleasona, a etapem T są bardziej przydatne niż sama ze sobą w przewidywaniu ostatecznego patologiczny Stage [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_155" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">155</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_176" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">176</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Modele te mogą przyczynić się do wyboru kandydatów do chirurgii oszczędzającej unerwienie i limfadenektomii (sekcja 7.2).</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Pęcherzyk nasienny inwazja jest predykcyjna wznowy miejscowej i przerzutów odległych awarii. </span><span style="margin: 0px; padding: 0px;">Pęcherzyk nasienny biopsji może poprawić dokładność przedoperacyjnej postoju [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_177" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">177</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">To nie jest zalecany do badania pierwszego rzutu, ale jest zarezerwowana dla pacjentów z wysokim ryzykiem SVI w których pozytywny biopsji będzie zmodyfikować leczenie. </span><span style="margin: 0px; padding: 0px;">Pacjenci z etapu T> 2a i PSA w surowicy> 10 ng / ml są kandydatami do SV biopsji [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_178" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">178</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_179" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">179</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">]. </span><span style="margin: 0px; padding: 0px;">Pacjenci z dodatnim biopsji od podstawy prostaty są bardziej prawdopodobne, aby mieć pozytywny biopsji SV [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_180" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">180</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Transperineal 3D mapping biopsji gruczołu krokowego (PMB) jest alternatywą dla biopsji przezodbytniczej ponieważ zapewnia bardziej precyzyjne umiejscowienie guza, stopień i Gleason klasyfikacji [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_181" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">181</span></a><span style="margin: 0px; padding: 0px;"> ], a ma akceptowalną zachorowalności.</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_1_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.1.3.</span></span><span style="margin: 0px; padding: 0px;"> Przezodbytniczej USG (TRUS)</span></h4>
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<span style="margin: 0px; padding: 0px;">Transrectal USG nie jest bardziej dokładne w przewidywaniu choroby narządów-ograniczone niż DRE [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_182" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">182</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_183" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">183</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Combined DRE i TRUS może wykryć T3A PCA dokładniej niż sam obu metod [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_184" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">184</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Nawet 3D-TRUS, środki Color Doppler i kontrastu może pomóc w lokalnej inscenizacji [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_185" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">185</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_186" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">186</span></a><span style="margin: 0px; padding: 0px;"> ], ale wszystkie techniki Trus są w dużej mierze zależny od operatora i nie można odróżnić guzy T2 i T3 z wystarczającą dokładnością zalecana do rutynowego inscenizacji.</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_1_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.1.4.</span></span><span style="margin: 0px; padding: 0px;"> Multiparametric rezonans magnetyczny (mpMRI)</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Obrazowanie T2-ważony pozostaje najbardziej użyteczna metoda miejscowego zaawansowania na mpMRI. </span><span style="margin: 0px; padding: 0px;">Na 1.5T (Tesla), mpMRI ma dobrą specyficzność, ale niską czułość w wykrywaniu fazy T3. </span><span style="margin: 0px; padding: 0px;">Zgromadzone dane z metaanalizy o przedłużenie extracapsular (EKG), SVI i ogólnej wykrywalności etap T3 wykazała czułość i swoistość 0,57 (95% CI: 0.49-0.64) oraz 0,91 (95% CI: 0.88-0.93), 0,58 ( 95% przedział ufności: 0.47-0.68) i 0,96 (95% CI: 0.95-0.97) i 0,61 (95% CI: 0.54-0.67) i 0,88 (95% CI: 0.85-0.91), odpowiednio, [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_187" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">187</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Multiparametric rezonans magnetyczny ma słabą czułość, ponieważ nie może wykryć mikroskopijne rozszerzenie extraprostatic. </span><span style="margin: 0px; padding: 0px;">Jej czułość zwiększa się wraz z promieniem przedłużenie ciągu okołosterczowej tłuszczu. </span><span style="margin: 0px; padding: 0px;">W jednym z badań, szybkość wykrywania ECE zwiększona z 14 do 100%, gdy promień przedłużenie wzrosła z <> 1 mm do 3 mm, [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_188" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">188</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W innym badaniu wrażliwości mpMRI, swoistość i dokładność wykrywania etap PT3 były, 40, 95 i 76%, odpowiednio, dla ogniskowej (tj mikroskopowych) extraprostatic przedłużenia, i 62, 95 i 88% dla szerokiej rozbudowy extraprostatic [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_189" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">189</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Zastosowanie wysokiej pola (3T) lub obrazowania funkcjonalnego oprócz obrazowaniu T2-ważony poprawia czułość wykrywania EKG lub SVI, ale doświadczenie czytelnika pozostaje kapitalne znaczenie [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_190" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">190</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Rezonans magnetyczny, choć nie idealny do miejscowego zaawansowania, może poprawić prognozowanie patologicznego stopnia w połączeniu z danymi klinicznymi [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_191" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">191</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_192" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">192</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Ze względu na jego niską czułość ogniskowej (mikroskopowym) rozszerzenie extraprostatic, mpMRI nie jest zalecany do miejscowego zaawansowania u chorych niskiego ryzyka [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_191" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">191</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_193" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">193</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_194" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">194</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Jednak mpMRI nadal może być przydatne do planowania leczenia u wybranych chorych niskiego ryzyka (np kandydatami do brachyterapii) [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_195" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">195</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.3.2.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> N-staging</span></span></span></h3>
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<a href="https://www.blogger.com/null" name="5_3_2_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.2.1.</span></span><span style="margin: 0px; padding: 0px;"> Poziom PSA oraz biopsji ustalenia</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">N-staging powinna być wykonywana tylko wtedy, gdy może bezpośrednio wpływać na decyzje dotyczące leczenia.</span><span style="margin: 0px; padding: 0px;">Wysokie wartości PSA, etap T2b T3, słaba różnicowania nowotworu i okołonerwowe inwazji wiążą się z wysokim ryzykiem wystąpienia przerzutów do węzłów chłonnych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_155" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">155</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_196" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">196</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_197" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">197</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Pomiar PSA sam jest pomocne w przewidywaniu przerzutów do węzłów chłonnych. </span><span style="margin: 0px; padding: 0px;">Nomogramy lub tabele PARTIN może zdefiniować pacjentów z grupy niskiego ryzyka (<10 adne="" bardziej="" by="" ch="" chocia="" cia="" do="" dok="" font="" mog="" nbsp="" nomogramy="" onnych="" przerzutami="" stopnia="" ustalaniu="" w="" z="" zaj=""></10></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_176" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">176</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_198" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">198</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Prosta formuła Roach mogą być również używane [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_199" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">199</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Pacjenci z niskiego i pośredniego ryzyka PCa może być oszczędzone N-staging przed potencjalnie radykalnego leczenia [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_155" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">155</span></a><span style="margin: 0px; padding: 0px;"> ].</span></span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Gleason 4 wzór w sekstant biopsji może określić ryzyko chorób N1. </span><span style="margin: 0px; padding: 0px;">Ryzyko związane z przerzutami do węzłów chłonnych było 20-45% jeśli rdzeń miał przeważającą Gleason wzór 4 lub> 3 rdzenie miał Gleason 4 wzór. </span><span style="margin: 0px; padding: 0px;">Dla pozostałych pacjentów, ryzyko wynosiło 2,5%, co sugeruje, że węzłowych Inscenizacja jest niepotrzebna u wybranych chorych [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_200" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">200</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_2_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.2.2.</span></span><span style="margin: 0px; padding: 0px;"> Nodal postoju za pomocą tomografii komputerowej i rezonansu magnetycznego multiparametric</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">CT jamy brzusznej i mpMRI pośrednio ocenić węzłową inwazji poprzez pomiar średnicy węzłów chłonnych. </span><span style="margin: 0px; padding: 0px;">Ich czułość jest niska i nie mogą być wykryte mikroskopowe inwazji. </span><span style="margin: 0px; padding: 0px;">Korzystanie próg 10 mm, czułość CT lub mpMR jest</span></span></div>
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<span style="margin: 0px; padding: 0px;"><40 font="" nbsp=""><a href="https://uroweb.org/guideline/prostate-cancer/#note_201-213" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">201-213</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Spośród 4.264 pacjentów, 654 (15,3%) miało pozytywne węzły chłonne w limfadenektomii, ale tylko 105 (2,5%) miało pozytywny TK. </span><span style="margin: 0px; padding: 0px;">Mediana oszacowano CT czułość, swoistość, NPV PPV było 7%, 100%, 85% i 100%, w [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_212" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">212</span></a><span style="margin: 0px; padding: 0px;"> ].</span></40></span></div>
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<span style="margin: 0px; padding: 0px;">Precyzyjna biopsji zasysania (BAC), mogą być użyteczne w przypadkach pozytywnego obrazowania, nawet jeśli ma ona fałszywie ujemne stopy o 40% [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_214" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">214</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Dla CT lub mpMRI wykrywanie mikroskopowej inwazji węzłów chłonnych wynosi <1 choroby="" font="" gleason="" lub="" miejscowe="" ml="" nbsp="" ng="" pacjent="" psa="" w="" wynikiem="" z=""><a href="https://uroweb.org/guideline/prostate-cancer/#note_209" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">209</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_215" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">215</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_216" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">216</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Tomografia komputerowa i mpMRI nie powinny być wykorzystywane do inscenizacji węzłowego u pacjentów niskiego ryzyka i być zarezerwowane dla nowotworów o wysokim stopniu ryzyka.</span></span></1></span></div>
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<a href="https://www.blogger.com/null" name="5_3_2_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.2.3.</span></span><span style="margin: 0px; padding: 0px;"> Limfadenektomia</span></h4>
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<span style="margin: 0px; padding: 0px;">Aktualnie dostępne są najbardziej optymalną metodą N-staging jest otwarta lub laparoskopowej limfadenektomii (patrz punkt 7.2.6).</span></div>
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<span style="margin: 0px; padding: 0px;">Pierwotne usunięcie węzeł wartowniczy ma na celu poprawę dokładności wykrywania węzłów łożyskowych guza przy jednoczesnym zmniejszeniu zachorowalności związanej z rozszerzonym miednicy węzłów chłonnych (LND) [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_217" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">217</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_218" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">218</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Wytyczne obrazu pozwala śródoperacyjnej węzeł wartowniczy (SN) Wykrywanie wizualnie [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_219" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">219</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Trudności w dostępie do SN oraz brak danych z dużych wieloośrodkowych kohort są główne ograniczenia tej techniki.</span><span style="margin: 0px; padding: 0px;">Dlatego na razie pozostaje to eksperymentalne [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_220" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">220</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3_3" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.3.3.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> M-staging</span></span></span></h3>
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<a href="https://www.blogger.com/null" name="5_3_3_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.3.1.</span></span><span style="margin: 0px; padding: 0px;"> Scyntygrafia kości</span></h4>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Scyntygrafia kości (BS) jest najczęściej stosowaną metodą oceny przerzutów kostnych PCA. </span><span style="margin: 0px; padding: 0px;">Jednakże, cierpi na stosunkowo niską specyficzność [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_221" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">221</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Zatem u pacjentów z niejednoznacznym ustalenia, zmiany muszą zostać ocenione przez innych technik obrazowania.</span></span></div>
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<span style="margin: 0px; padding: 0px;">NPV dla skanowania kości jest 87-100% [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_214" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">214</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_222-230" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">222-230</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Jego wydajność diagnostyczną jest znacząco wpływał poziom PSA, stadium kliniczne i guz skali Gleasona [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_222-235" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">222-235</span></a><span style="margin: 0px; padding: 0px;"> ], a te trzy czynniki były jedynymi niezależnymi predyktorami BS dodatni w badaniu obejmującym 853 pacjentów [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_236" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">236</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Stopa dodatni BS jest bardzo niskie (<1 font="" nbsp="" niskiego="" pacjent="" ryzyka="" u="" w=""></1></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_235" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">235</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_237-239" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">237-239</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W przeciwieństwie do tego, jest 6,6 - 38,5% u pacjentów z poziomem PSA</span></span></span></div>
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<span style="margin: 0px; padding: 0px;">20-50 ng / ml [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_222" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">222</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_225-228" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">225-228</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_230" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">230</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_231" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">231</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_237-239" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">237-239</span></a><span style="margin: 0px; padding: 0px;"> ], 19 - 90,7% pacjentów w stadium> T3 [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_222" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">222</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_226" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">226</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_228" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">228</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_229" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">229</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_231" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">231</span></a><span style="margin: 0px; padding: 0px;"> ,</span><a href="https://uroweb.org/guideline/prostate-cancer/#note_237" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">237</span></a><span style="margin: 0px; padding: 0px;"> ], a 16,9 - 29,6% u pacjentów z Gleason> 8 nowotworów [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_233" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">233</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_234" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">234</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_237" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">237</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_239" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">239</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Proporcja pozytywnej BS u pacjentów z poziomem PSA w 10 - 20 ng / ml (1-33.3%) lub Gleason 7 (2,8 - 22%) jest bardzo zmienna z jednego badania na drugie [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_214" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">214</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_222" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">222</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_223" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">223</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_225-229" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">225-229</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_238-240" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">238-240</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W dwóch badaniach głównym Gleason wzór 4 stwierdzono, że istotnym predyktorem pozytywnej BS [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_238" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">238</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_240" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">240</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<div class="bodytekst_inspringen_eerste" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: -18px 0px 0px; outline: 0px; padding: 0px 0px 20px; text-indent: 80px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Skanowanie kości należy wykonać u pacjentów objawowych, niezależnie od poziomu PSA, Gleasona lub stadium klinicznym [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_212" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">212</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3_4" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.3.4.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Nowe metody obrazowania</span></span></span></h3>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_4_1" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.4.1.</span></span><span style="margin: 0px; padding: 0px;"> Przerzutami do węzłów chłonnych</span></h4>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span class="superscript" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 10px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: top;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">11</span></span></span><span style="margin: 0px; padding: 0px;"> C- lub  </span><span class="superscript" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 10px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: top;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">18</span></span></span><span style="margin: 0px; padding: 0px;"> M-cholina pozytonowej tomografii emisyjnej (PET) / CT mają dobrą specyficzność przerzutów do węzłów chłonnych, lecz czułość między 10-73% [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_241" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">241</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_242" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">242</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">W meta-analizie 609 pacjentów, połączonej czułości i swoistości choliny PET / CT w miednicy przerzutów do węzłów chłonnych wynosił 62% (95% CI: 51 - 66%) i 92% (95% CI: 89 - 94%), odpowiednio, [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_243" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">243</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">W prospektywnym badaniu 75 pacjentów z pośrednim ryzykiem zajęcia węzłów chłonnych (10-35%), czułość tylko 8,2% w regionie w oparciu i 18,9% w analizie opartej pacjenta, która jest zbyt mała, aby z klinicznego publicznej [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_244" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">244</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Dlatego, cholina PET / CT nie ma miejsca dla wstępnymi inscenizacji w węzłowych przerzutów. </span><span style="margin: 0px; padding: 0px;">Obecnie, antygen specyficzny dla prostaty PET membrana CT (PSMA PET / CT) pozostaje badany.</span></span></div>
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<span style="margin: 0px; padding: 0px;">Czułość Rezonans magnetyczny jest niska przerzutów do węzłów chłonnych i podobne [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_245" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">245</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_246" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">246</span></a><span style="margin: 0px; padding: 0px;"> ] lub gorsze [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_247" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">247</span></a><span style="margin: 0px; padding: 0px;"> ] W tym choliny PET / CT.</span></div>
<h4 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 20px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<a href="https://www.blogger.com/null" name="5_3_4_2" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;">5.3.4.2.</span></span><span style="margin: 0px; padding: 0px;"> Bone przerzuty</span></h4>
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<span class="superscript" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 10px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: top;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">18</span></span></span><span style="margin: 0px; padding: 0px;"> F-fluorek PET lub PET / CT pokazuje podobną specyfikę i doskonałą czułość na skanowaniu kości [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_241" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">241</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_248-252" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">248-252</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Jednakże, w przeciwieństwie do choliny PET / CT, nie wykrywa przerzutów do węzłów chłonnych, i jest mniej ekonomiczny w porównaniu do skanowania kości [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_252" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">252</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Pozostaje niejasne, czy  </span><span class="superscript" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 10px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: top;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">11</span></span></span><span style="margin: 0px; padding: 0px;"> C-choliny PET / CT jest bardziej czuły niż tradycyjne skanowanie kości, ale ma wyższą specyficzność, mniej nieokreślonych zmian kostnych [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_241" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">241</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_243" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">243</span></a><span style="margin: 0px; padding: 0px;"> , </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_253" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">253</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">Dyfuzja ważony całego ciała i osiowe MRI są bardziej wrażliwe niż skanowania kości i ukierunkowane radiografii w wykrywaniu przerzutów kostnych w wysokim stopniu ryzyka PCA [ </span><a href="https://uroweb.org/guideline/prostate-cancer/#note_254-256" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">254-256</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]. </span><span style="margin: 0px; padding: 0px;">Całe ciało mpMRI jest bardziej czułe i specyficzne niż połączonej scyntygrafia kości, ukierunkowanych radiografii i abdominopelvic CT [ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_257" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">257</span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ].</span><span style="margin: 0px; padding: 0px;">Niedawny metaanalizy stwierdzili, że mpMRI jest bardziej wrażliwa niż cholina PET / CT oraz BS w wykrywaniu przerzutów kostnych w przeliczeniu na pacjenta, chociaż cholina PET / CT miał najwyższą swoistość (tabela 5.3.1) [</span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_258" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;">258</span></a><span style="margin: 0px; padding: 0px;"> ].</span></div>
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<span style="margin: 0px; padding: 0px;">5.3.1Sensitivity Tabela i swoistość w wykrywaniu przerzutów kostnych w przeliczeniu na pacjenta  </span><span class="bodytekst" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">[ </span></span><a href="https://uroweb.org/guideline/prostate-cancer/#note_258" style="-webkit-font-smoothing: antialiased; -webkit-tap-highlight-color: rgb(0, 160, 227); background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">258</span></span></a><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> ]</span></span></span></div>
<table class="tabel_zwart-wit" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 1px solid rgb(102, 102, 102); box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"></th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Wrażliwość%</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Specyficzność%</span></div>
</th><th class="Celstijl_1_tint_zwart" style="-webkit-font-smoothing: antialiased; background: rgb(240, 240, 240); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
CI</div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Bone Modalność skanowania</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
78</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
85</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
95% (0.73-0.83)</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZWIERZĘ DOMOWE</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
91</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
99</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
95% (0.83-0.96)</div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">mpMRI</span></div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
97</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
95</div>
</td><td class="Celstijl_1" style="-webkit-font-smoothing: antialiased; background: rgb(255, 255, 255); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="25%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
95% (0.91-0.99)</div>
</td></tr>
</tbody></table>
<div class="bodytekst_italic_onder_tabel 1e regel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">CI = przedział ufności; </span><span style="margin: 0px; padding: 0px;">mpMRI = multiparametric rezonans magnetyczny; </span><span style="margin: 0px; padding: 0px;">= Emisyjnej PET</span></span></div>
<div class="bodytekst_italic_onder_tabel" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; line-height: 18px; margin: -15px 0px 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">tomografia.</span></div>
<div class="bodytekst" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px; outline: 0px; padding: 0px 0px 20px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">Mimo dowodów wskazuje, że cholina PET / CT i mpMRI są dokładniejsze niż BS, te techniki są obecnie ograniczone przez brak dostępności. </span><span style="margin: 0px; padding: 0px;">Kliniczne korzyści wykrywania przerzutów kostnych na wcześniejszym punkcie czasowym przy użyciu bardziej czułych technik również pozostaje niejasna w początkowym ustawieniu pomostowym. </span><span style="margin: 0px; padding: 0px;">skan kości jest więc zwykle korzystne w większości ośrodków.</span></span></div>
<h3 style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; font-style: italic; font-weight: 400; line-height: 30px; margin: 0px 0px 0px 80px; outline: 0px; padding: 0px; position: relative; text-rendering: optimizeLegibility; vertical-align: baseline;">
<span class="kop3_bolditalic" style="background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><a href="https://www.blogger.com/null" name="5_3_5" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; color: #2cace1; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: none; padding: 0px; text-decoration: none; transition: opacity 0.3s, color 0.3s; vertical-align: baseline;"></a><span class="list" style="background: 0px 0px; border: 0px; box-sizing: border-box; display: inline-block; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 400; line-height: inherit; margin: 0px 0px 0px -80px; outline: 0px; padding: 0px; vertical-align: baseline; width: 80px;"><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">5.3.5.</span></span></span><span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;"> Wytyczne dotyczące stopnia zaawansowania raka stercza</span></span></span></h3>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Każda inscenizacja grupa ryzyka</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie używać CT i TRUS lokalnej inscenizacji.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
</tbody></table>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Niskiego ryzyka zlokalizowane PCa</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Nie używać dodatkowego obrazowania w celach postoju.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
</tbody></table>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">PCa pośrednim ryzykiem</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">W przeważającej Gleason wzór 4, przerzutowym przesiewowych obejmuje co najmniej przekroju obrazowania abdominopelvic i CT / MRI i kością skanowania na potrzeby postoju.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA*</span></div>
</td></tr>
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">W przeważającej Gleason wzór 4, użyj prostaty mpMRI lokalnej inscenizacji i przerzutami przesiewowych.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
</tbody></table>
<table class="tabel_blauw" style="-webkit-font-smoothing: antialiased; background: 0px 0px rgb(245, 245, 245); border-collapse: collapse; border-spacing: 0px; border: 0px; box-sizing: border-box; color: #2c2b2b; font-family: Roboto, 'Helvetica Neue', Helvetica, Arial, sans-serif; font-size: 15px; font-stretch: inherit; line-height: 18px; margin: 0px 0px 20px; max-width: 100%; outline: 0px; padding: 0px; table-layout: auto; vertical-align: baseline; width: 693px;"><thead style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Wysokiego ryzyka zlokalizowane PCa / wysokiego ryzyka miejscowo zaawansowanym PCA</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">LE</span></div>
</th><th class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 1.2rem; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 500; line-height: 1.4667rem; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekstbold_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: 16px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: 700; line-height: 18px; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">GR</span></div>
</th></tr>
</thead><tbody style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<tr style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;"><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="87%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">Użyj prostaty mpMRI lokalnej inscenizacji.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2b</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
</td></tr>
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<span style="margin: 0px; padding: 0px;">Wykonaj przerzutowy przesiewowe w tym co najmniej przekroju obrazowania abdominopelvic i kości-scan.</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">2a</span></div>
</td><td class="Celstijl_1_tint_PMS" style="-webkit-font-smoothing: antialiased; background: rgb(197, 218, 241); border: 1px solid rgb(102, 102, 102); box-sizing: border-box; font-family: inherit; font-size: 13px; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 3px 5px; vertical-align: top;" width="7%"><div class="tabel_bodytekst_9pt" style="-webkit-font-smoothing: antialiased; background: 0px 0px; border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; outline: 0px; padding: 0px; vertical-align: baseline;">
<span style="margin: 0px; padding: 0px;">ZA</span></div>
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<span style="margin: 0px; padding: 0px;">* Ulepszony po panelu konsensusu.</span></div>
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<span style="margin: 0px; padding: 0px;"><span style="margin: 0px; padding: 0px;">CT = tomografia komputerowa; </span><span style="margin: 0px; padding: 0px;">mpMRI = multiparametric rezonans magnetyczny; </span><span style="margin: 0px; padding: 0px;">PCa = raka prostaty; </span><span style="margin: 0px; padding: 0px;">PET = pozytonowej tomografii emisyjnej; </span><span style="margin: 0px; padding: 0px;">TRUS = przezodbytniczej USG.</span></span></div>