GORĄCZKA LASSA (ang. LASSA FEVER)

Wirus Lassa powoduje endemiczne i epidemiczne zachorowania na terenie Nigerii, Gwinei, Liberii i Sierra Leone, aczkolwiek z dużym prawdopodobieństwem występuje on na znacznie większym obszarze zachodniej Afryki. Wirus Lassa (podobnie jak inne arenawirusy) przenosi się na człowieka za pośrednictwem aerozolu wydalanego przez przewlekle zakażone gryzonie. Do zakażenia dochodzi podczas łapania lub zjadania tych zwierząt. Wirus może także przenosić się przez bliskie kontakty międzyludzkie. Często obecny jest w moczu w okresie zdrowienia, podejrzewa się również jego obecność w płynie nasiennym we wczesnej fazie zdrowienia. Chorują ludzie w każdym wieku i obojga płci. 

1. GORĄCZKA LASSA - EPIDEMIOLOGIA

Zapadalność jest najwyższa w porze suchej, lecz zakażenia mają miejsce przez cały rok. W krajach, w których wirus Lassa występuje endemicznie, gorączka Lassa może stanowić dominujący odsetek zachorowań gorączkowych. Przykładowo w Sierra Leone potwierdzona laboratoryjnie choroba jest stale odpowiedzialna za 20% przyjęć na oddziały szpitalne. Prawdopodobnie w samej Afryce Zachodniej corocznie występują dziesiątki tysięcy przypadków schorzenia.

2. GORĄCZKA LASSA - OBRAZ KLINICZNY

Wśród czynników etiologicznych gorączek krwotocznych jedynie arenawirusy są przyczyną typowego stopniowego rozwoju choroby. Najczęściej obserwuje się stopniowy początek choroby, z pojawianiem się coraz cięższych objawów ogólnoustrojowych. Krwawienie obserwowane jest jedynie w około 15-30% przypadków. 

U pacjentów o jasnej karnacji często można zauważyć plamistogrudkową wysypkę. Wybroczyny są częste. Później, przeważnie u mężczyzn, może dochodzić do zapalenia osierdzia. Wskaźnik śmiertelności płodów w ostatnim trymestrze ciąży wynosi 92%. Ryzyko zgonu matek jest również wyższe i wynosi 30%, w porównaniu z 15% obserwowanymi w populacji ogólnej chorych. Fakty te mogą sugerować rozważenie przerwania ciąży u zakażonych kobiet.

Liczba krwinek białych jest prawidłowa lub lekko podwyższona, a liczba płytek krwi jest prawidłowa lub nieco obniżona. Głuchota zbiega się w czasie z poprawą kliniczną u około 20% przypadków i jest trwała. U niektórych chorych ma charakter obustronny. Ponowne zakażenie może wystąpić, ale jego przebieg zazwyczaj jest łagodny.

3. GORĄCZKA LASSA - BADANIA LABORATORYJNE, LECZENIE

Wysoka wiremia bądź wysoka aktywność w surowicy AspAT stanowią złe rokowniczo czynniki prognostyczne. Chorzy z aktywnością aminotransferazy asparaginianowej powyżej 150 IU/ml powinni być leczeni dożylnie rybawiryną. Wydaje się, że ten lek przeciwwirusowy (analog nukleozydowy) skutecznie zmniejsza wskaźniki śmiertelności, co udało się wykazać w retrospektywnych badaniach kontrolowanych. Jego jedynym istotnym działaniem niepożądanym jest odwracalna niedokrwistość, która zwykle nie wymaga przetoczenia krwi.

Lek powinien być podany w powolnym wlewie dożylnym w dawce 32 mg/kg; następnie stosuje się 16 mg/kg co 6 godzin przez 4 dni, potem 8mg/kg co 8 godzin przez 6 dni. 

KATEGORIA: CHOROBY ZAKAŹNE, MEDYCYNA MORSKA I TROPIKALNA, MIKROBIOLOGIA

TAGI: 101 fever 102 fever 103 fever 103 fever in children 105 fever a fever a viral illness a viral infection about dengue fever about ebola fever about ebola virus in nigeria about tb about tuberculosis about viral fever about viral infection acute rheumatic fever acute viral illness acute viral infection adult fever adult fevers africa and ebola africa ebola disease african fever lassa afternoon fever all about tuberculosis allergies and fever allergies fever allergies with fever allergy fever antibiotic fever article ebola virus asthma and fever autoreifen lassa babies fever babies with fever baby fever baby fever 102 baby fever chart baby fever medicine baby fever reducer baby fever teething baby fever temperature baby fever temperature chart baby fever what to do baby fevers baby has fever baby high fever baby rash after fever baby teething fever baby temperature baby temperature chart baby temperature fever baby temperature range baby throwing up no fever baby vomiting no fever baby with fever bacillary dysentery barum barum bravuris 2 barum lastik fiyatları beaver fever best fever reducer best fever thermometer bird flu black fever black water fever blackwater fever body aches and fever body aches no fever body temperature chart fever body temperature fever body temperature fever chart bovine tuberculosis brain fever brain fever causes brain fever symptoms break a fever breaking a fever can allergies cause a fever can allergies cause fever can constipation cause fever can dehydration cause fever can stress cause fever can teething cause fever can you get a fever with allergies can you get glandular fever twice can you have a fever with allergies can you have flu without fever can you have meningitis without a fever can you have pneumonia without fever can you have strep throat without a fever can you have the flu without a fever can you have the flu without fever can you run a fever with allergies canine fever cat fever cat fever symptoms cat scratch fever pictures cat scratch fever symptoms cat scratch fever treatment cat with fever cause ebola virus cause for ebola cause of ebola cause of ebola fever cause of ebola virus cause of fever cause of lassa fever cause of the ebola virus cause of viral fever cause of viral infection cause of virus cause the ebola virus causes ebola hemorrhagic fever causes of dengue fever causes of ebola virus infection causes of fever causes of fever in children causes of high fever causes of lassa fever causes of low grade fever causes of night fever causes of tb causes of the ebola disease causes of tuberculosis causes of typhoid fever cedar fever chikungunya fever child fever child fever 103 child fever chart child temperature child throwing up no fever child vomiting no fever child vomiting without fever child with fever childbed fever children and fevers children fever children fever chart children with fever childrens fever childrens temperature childrens temperature chart chills chills and fever chills but no fever chills no fever chills with no fever chills without fever colds common flu symptoms constant fever constipation and fever consumption disease cotton fever cough cough and fever cough fever crimean congo hemorrhagic fever dance fever dangue fever deadly disease deadly diseases definition of ebola hemorrhagic fever definition of fever definition of hemorrhagic fever definition of tuberculosis definition of viral fever denge fever dengi fever dengu fever dengue fever dengue fever causes dengue fever diagnosis dengue fever information dengue fever pictures dengue fever platelet count dengue fever rash dengue fever rash pictures dengue fever symptoms dengue fever symptoms in children dengue fever treatment dengue fever vaccine dengue fever virus dengue hemorrhagic fever dengy fever denque fever desert fever diagnosed with a viral infection diagnosis virus diarrhea diarrhea and fever diarrhea fever diarrhea vomiting no fever different types of fever digital fever thermometer disease caused by virus in animals dizziness do allergies cause fever do i have the flu does teething cause fever dog fever dog fever symptoms dog with fever dogs with fever drug fever dry cough and fever dunlop dunlop lastik dunlop sp sport dunlop sp sport 01 dunlop sp sport maxx dunlop sp winter sport 3d dunlop sport 01 dunlop sport maxx ebola and ebola and africa ebola and west africa ebola cause ebola caused by ebola disease cause ebola disease in nigeria ebola disease in west africa ebola disease information ebola disease nigeria ebola disease origin ebola disease transmission ebola disease west africa ebola fever ebola fever in africa ebola fever in nigeria ebola fever news ebola fever nigeria ebola fever transmission ebola fever virus ebola hemorrhagic fever ebola in africa ebola in west africa ebola in west afrika ebola in western africa ebola lassa ebola situation in west africa ebola the virus ebola transmitted ebola viral fever ebola viral hemorrhagic fever ebola viral infection ebola virus and causes ebola virus areas ebola virus cause ebola virus caused by ebola virus causes symptoms and treatment ebola virus disease west africa ebola virus ebola ebola virus from ebola virus how is it transmitted ebola virus illness ebola virus in ebola virus in africa ebola virus in west africa ebola virus infection ebola virus infections ebola virus is caused by what ebola virus is transmitted by ebola virus transmission to humans ebola virus transmitted ebola virus update west africa ebola virus virus ebola virus what causes it ebola virus what is ebola virus what is it ebola viruses ebola viruses are transmitted by ebola vırus enteric fever facts about tb facts about tuberculosis falken falken lastik falken lastik fiyatları familial mediterranean fever fashion fever federal lastik fever fever 102 fever 103 fever 105 fever 1793 fever adults fever after eating fever after surgery fever and allergies fever and body aches fever and chills fever and chills in adults fever and cough fever and diarrhea fever and flu fever and headache fever and headache in children fever and hives fever and rash fever and rash in children fever and sore throat fever and teething fever and throwing up fever and viral infection fever and virus fever and vomiting fever and vomiting in children fever at night fever at night only fever babies fever baby fever blister fever blister on lip fever blisters fever breaking fever caused by viral infection fever causes fever chart fever chart for adults fever chart for children fever chart for infants fever child fever children fever chills fever chills body aches fever chills headache fever clothing fever conversion fever conversion chart fever cough fever definition fever designs fever diarrhea fever dog fever dream fever ebola fever flu fever for 3 days fever for 5 days fever for adults fever for babies fever from allergies fever from viral infection fever from virus fever headache fever headache nausea fever in adults fever in babies fever in babies when to worry fever in baby fever in cats fever in children fever in children 103 fever in children when to worry fever in dogs fever in infant fever in infants fever in infants when to worry fever in kids fever in spanish fever in the evening fever in toddler fever in toddlers fever in toddlers when to worry fever in viral infection fever infant fever infection or virus fever kids fever london fever medication fever medicine fever medicine for children fever no other symptoms fever of 102 fever of 103 fever of unknown origin fever only at night fever pathophysiology fever range fever rash fever rash pictures fever rash sore throat fever rash toddler fever rashes fever reducer fever reducer for adults fever reducer for dogs fever reducer for kids fever reducers for adults fever reduction fever relief fever remedies fever scale fever seizure fever sore throat fever sweating fever symptoms fever symptoms in adults fever teething fever temp fever temperature fever temperature chart fever temperature children fever temperature conversion fever temperature conversion chart fever temperature for babies fever temperature range fever temperature range adults fever temperatures fever thermometer fever thermometers fever toddler fever treatment fever treatment for adults fever viral fever virus fever virus in children fever virus symptoms fever viruses fever wiki fever with a virus fever with allergies fever with chills fever with flu fever with headache fever with no other symptoms fever with no other symptoms in children fever with period fever with pink eye fever with rash fever with rash in children fever with rashes fever with teething fever with viral infection fever with virus fever without other symptoms feveral seizures fevers fevers in adults fevers in babies fevers in children fevers in infants fevers in toddlers flu flu a flu and fever flu contagious period flu duration flu facts flu fever flu fever duration flu in children flu like symptoms flu like symptoms no fever flu like symptoms without fever flu no fever flu remedies flu symptom flu symptoms flu symptoms in adults flu symptoms in children flu symptoms no fever flu symptoms without fever flu symptons flu symtoms flu treatment flu virus flu virus symptoms flu without fever food poisoning and fever food poisoning fever food poisoning symptoms foot fever frequent fevers friday night fever galangal fever gladular fever glandula fever glandular fever glandular fever children glandular fever chronic fatigue syndrome glandular fever contagious glandular fever in adults glandular fever in children glandular fever rash glandular fever recovery glandular fever recurrence glandular fever relapse glandular fever symptoms glandular fever symptoms in adults glandular fever treatment glandular fever wiki good year good year lastik fiyatları goodyear goodyear duragrip goodyear eagle goodyear eagle nct5 goodyear gt2 goodyear gt3 goodyear hydragrip goodyear lastik goodyear optigrip gorączka gorączka lassa h1n1 h1n1 flu h1n1 virus hay fever hay fever in babies hay fever in children hay fever injection hay fever remedies hay fever season hay fever symptoms hay fever treatment headache and fever headache fever headache with fever headaches headaches and fever health fever health viruses hemorrhagic ebola virus hemorrhagic fever hemorrhagic fever definition hemorrhagic fever ebola virus hemorrhagic virus definition het ebola virus hey fever high fever high fever adults high fever and rash high fever in adults high fever in babies high fever in children high fever in infants high fever in kids high fever in toddlers high fever no other symptoms high fever symptoms high fever temperature high fever treatment high fevers high fevers in children high fevers in toddlers high grade fever high temperature in children hiv fever hives and fever hives with fever home remedies for fever home remedies for fever in children home remedies for the flu horse fever how can you get a viral infection how do you break a fever how do you get a fever how do you get a viral infection how do you get ebola fever how do you get scarlet fever how do you get tb how do you get tuberculosis how do you get viral infection how ebola virus is transmitted how ebola virus transmitted how high is a fever how high is too high for a fever how is ebola disease transmitted how is ebola virus caused how is ebola virus transmitted how is lassa fever spread how is lassa fever transmitted how is the ebola virus caused how is the ebola virus transmitted how long does a fever last how long does a fever last with the flu how long does fever last with flu how long does flu last how long should a fever last how long should a fever last in a child how the ebola virus is transmitted how to beat a fever how to break a fever how to break a fever in a child how to break a fever in adults how to bring a fever down how to bring down a fever how to bring down a fever in a child how to bring down a high fever how to fake a fever how to fight a fever how to get a fever how to get a fever fast how to get a fever overnight how to get a high fever how to get fever how to get fever fast how to get fever in an hour how to get fever overnight how to get high fever how to get rid of a fever how to get rid of a fever fast how to get rid of fever how to have a fever how to have fever how to induce a fever how to lower a fever how to lower fever how to make yourself have a fever how to reduce a fever how to reduce a fever in adults how to reduce fever how to reduce fever in adults how to reduce fever in children how to stop a fever how to treat a fever how to treat fever how to treat glandular fever how to treat high fever how to treat tb how to treat the flu human body temperature fever human temperature fever hypersensitivity pneumonitis i have a fever i have fever ibuprofen fever illness africa illness caused by virus illness in africa images of scarlet fever images of scarlet fever rash impetus revo lassa in west africa infant fever infant fever chart infant fever medicine infant fever temperature infant fever treatment infant fevers infant temperature infant temperature chart infant vomiting no fever infants fever infection ebola virus influenza influenza a symptoms influenza b influenza symptoms influenza treatment information about tuberculosis information on tb information on tuberculosis intermittent fever internal fever internal fever symptoms is dengue fever contagious is ebola disease in nigeria is ebola fever in nigeria is ebola virus in nigeria is fever a sign of pregnancy is glandular fever contagious is scarlet fever contagious is the ebola virus in nigeria is valley fever contagious kid fever kids fever kids fever chart kids temperature kinds of fever kitten fever kumho kumho ku31 kumho lastik kumho solus kh17 la tuberculosis lassa lassa at lassa atracta lassa atracta nasıl lassa atracta yorum lassa autoreifen lassa bayileri lassa competus at lassa ebola lassa fever lassa fever cdc lassa fever diagnosis lassa fever ebola lassa fever encephalitis lassa fever epidemiology lassa fever facts lassa fever history lassa fever in nigeria lassa fever minnesota lassa fever nigeria lassa fever pictures lassa fever rat lassa fever symptoms lassa fever transmission lassa fever treatment lassa fever vaccine lassa fever virus lassa fever wiki lassa fever คือ lassa fiyatlar lassa gomme lassa hemorrhagic fever lassa impetus lassa impetus 2 lassa impetus revo lassa impetus sport lassa lassa lassa lastik lassa nigeria lassa pneu lassa pneumatici lassa rat lassa reifen lassa snoways lassa sommerreifen lassa tire lassa tires lassa town lassa transway lassa tyre lassa tyres lassa tyres review lassa tyres turkey lassa tyres uk lassa viral lassa virus lassa virus transmission lassa viruses lassa winter tyres lassa winterreifen lastik park low body temperature low body temperature fever low fever low fever temperature low grade fever low grade fever after surgery low grade fever causes low grade fever in adults low grade fever in children low grade fever range low grade fever symptoms low grade fevers low temperature fever malaria fever malarial fever marshall lastik maxxis lastik medical fever medical virus medicine for fever mediterranean fever metzeler mild fever milk fever mud fever mud fever in horses muscle aches muscle pain my baby has a fever my dog has a fever nankang natural fever reducer nausea and fever neutropenic fever new virus in west africa newborn fever nigeria ebola virus night fevers nokian nokian lastik normal body temperature children normal body temperature for children normal body temperature for kids normal fever temperature normal temperature for a child normal temperature for children nursing diagnosis for fever nursing intervention for fever nursing interventions for fever on and off fever origin of ebola disease origin of ebola fever origin of lassa fever paratyphoid fever parrot fever pathogenesis of lassa fever pathophysiology of fever pediatric fever people affected by ebola virus people with ebola disease periodic fever syndrome persistent fever persistent low grade fever petlas petlas lastik pharyngoconjunctival fever pictures of dengue fever pictures of scarlet fever pictures of scarlet fever rash pink eye and fever pink eye with fever pireli pirelli pirelli cinturato pirelli cinturato p1 pirelli cinturato p4 pirelli cinturato p6 pirelli cinturato p7 pirelli diablo pirelli p zero pirelli p zero rosso pirelli p2500 pirelli p3000 pirelli p6 pirelli p6 cinturato pirelli p6000 pirelli p7 pirelli p7 cinturato pirelli p7000 pirelli scorpion pirelli scorpion str pirelli scorpion verde pirelli scorpion zero pirelli tires pneumatici lassa impetus revo pneumonia without fever pneus postoperative fever potomac horse fever prelli prolonged fever prolonged fever in children puerperal fever pulmonary tuberculosis q fever q fever symptoms rabbit fever rash after fever rash and fever rash fever rash from fever rash with fever rashes rashes after fever rashes with fever rat bite fever rat fever reasons for fever recurring fever reduce fever reducing fever in adults reducing fever in children reifen lassa relapsing fever remedies for fever reye syndrome rheumatic fever in adults rheumatic fever in children rheumatic fever pictures rheumatic fever symptoms rheumatic fever treatment rhumatic fever ribavirin lassa fever rift valley fever rocky mountain fever rocky mountain spotted fever rash running a fever salmonellosis scarlet fever scarlet fever and pregnancy scarlet fever contagious scarlet fever history scarlet fever images scarlet fever in adults scarlet fever in babies scarlet fever in children scarlet fever incubation period scarlet fever pictures scarlet fever pictures of rash scarlet fever rash scarlet fever rash images scarlet fever rash picture scarlet fever rash pictures scarlet fever rash treatment scarlet fever symptoms scarlet fever symptoms in adults scarlet fever symptoms in children scarlet fever treatment scarlets fever scarlett fever scarlette fever severe sore throat no fever shivering without fever side effects of fever signs and symptoms of dengue fever signs of a fever signs of dengue fever signs of fever signs of flu signs of lassa fever signs of mono signs of scarlet fever signs of tb signs of the flu signs of valley fever sommerreifen lassa sore throat sore throat and fever sore throat fever sore throat no fever sore throat with fever sore throat without fever spring fever stages of fever starmaxx lastik starve a fever stomach flu stomach flu treatment strep symptoms strep throat no fever strep throat without fever stress fever sudden fever swamp fever sweating out a fever swine flu swine flu symptoms swine flu treatment symptom checker symptoms dengue fever symptoms glandular fever symptoms of a fever symptoms of brain fever symptoms of dengue fever symptoms of dengue fever in children symptoms of fever symptoms of flu symptoms of glandular fever symptoms of influenza symptoms of lassa fever symptoms of malaria fever symptoms of rheumatic fever symptoms of scarlet fever symptoms of scarlet fever in adults symptoms of tb symptoms of the flu symptoms of tuberculosis symptoms of typhoid fever symptoms of valley fever symptoms of viral fever symptoms of viral fever in children symptoms of yellow fever symtoms of dengue fever tb tb disease tb facts tb images tb in children tb infection tb information tb symptoms teething and fever teething fever temperature temperature fever temperature fever chart temperature for fever temperature in children temperature of a fever temperature of fever the cause of ebola the cause of ebola disease the cause of ebola virus the cause of fever the ebola virus the ebola virus in africa the ebola virus in nigeria the flu the flu symptoms the flu virus the lassa ward the virus ebola the virus of ebola thermometer fever throwing up and diarrhea no fever throwing up no fever throwing up with no fever thyphoid fever thypoid fever thyroid fever tick bite fever in dogs tick fever tick fever in dogs tick fever in humans tified fever tires toddler fever toddler fever 102 toddler fever chart toddler high fever toddler temperature toddler vomiting no fever toddler with fever toyo toyo lastik toyo tires transmission of ebola disease transmission of lassa fever treat a fever treating a fever treating fever treating the flu treatment for dengue fever treatment for fever treatment for flu treatment for glandular fever treatment for scarlet fever treatment for tb treatment for the flu treatment of dengue fever treatment of fever treatment of tb treatment of typhoid fever trench fever tuberclosis tubercolosis tuberculose tuberculoses tuberculosis tuberculosis causes tuberculosis contagious tuberculosis disease tuberculosis facts tuberculosis history tuberculosis information tuberculosis pictures tuberculosis symptoms tuberculosis symptoms and signs tumor fever types of fever types of fevers typhoid fever history typhoid fever pictures typhoid fever symptoms typhoid fever treatment typhus fever undulant fever unexplained fever unexplained fever in children valley fever valley fever in dogs valley fever symptoms valley fever treatment viral fever viral fever cause viral fever definition viral fever diagnosis viral fever in children viral fever in kids viral fever in toddlers viral fever infection viral fever symptoms viral fever virus viral flu viral hemorrhagic fever viral hemorrhagic fever definition viral hemorrhagic fever ebola viral illness viral infection viral infection and fever viral infection cause viral infection diagnosis viral infection fever viral infection uk viral infection what is it viral infection with fever viral rna viral virus virus and fever virus ebola nigeria virus en nigeria virus fever virus illness virus in humans virus in nigeria virus infection virus lassa virus nigeria virus of ebola virus symptoms virus systems virus with fever viruses and fever viruses infection viruses that cause fever vomiting and fever vomiting and fever in children vomiting diarrhea no fever vomiting no fever vomiting without fever ways to reduce fever west africa and ebola west africa ebola news west africa ebola update west african countries affected by ebola west afrika ebola west nile fever west nile virus facts what a viral infection what are flu symptoms what are the cause of fever what are the causes of ebola disease what are the causes of ebola fever what are the symptoms ebola virus what are the symptoms of dengue fever what are the symptoms of scarlet fever what are viral infection what cause a fever what cause ebola disease what cause ebola virus what cause fever what cause the ebola virus what cause viral infection what cause virus what caused the ebola virus what causes a fever what causes dengue fever what causes fever what causes night fever what causes tb what causes tuberculosis what causes yellow fever what does a low grade fever mean what illness is caused by a virus what is a fever what is a fever blister what is a fever caused by what is a fever for a baby what is a fever in adults what is a fever temperature what is a fever virus what is a flu what is a high fever what is a high fever for a baby what is a high fever for adults what is a high fever in adults what is a low grade fever what is a low grade fever in adults what is a viral fever what is a viral illness what is a viral infection what is a viral infection caused by what is a virus in humans what is acute viral infection what is an acute viral infection what is an viral infection what is brain fever what is cabin fever what is cat scratch fever what is cause of ebola virus what is cause of fever what is considered a fever what is considered a high fever what is considered a low grade fever what is dengue fever what is ebola caused by what is ebola fever what is ebola virus caused by what is ebola virus infection what is fever what is fever caused by what is fever temperature what is fever virus what is flu what is glandular fever what is hay fever what is high fever what is influenza what is lassa what is lassa fever what is lassa virus what is low grade fever what is q fever what is rheumatic fever what is scarlet fever what is swine flu what is tb what is tb disease what is the cause ebola virus what is the cause of a fever what is the cause of ebola fever what is the cause of ebola virus what is the cause of fever what is the cause of lassa fever what is the cause of the ebola virus what is the cause of viral infection what is the cause of virus what is the causes of ebola virus what is the ebola virus caused by what is the fever virus what is the flu what is the normal temperature what is the temperature for a fever what is the viral infection what is tuberculosis what is tuberculosis disease what is typhoid fever what is valley fever what is viral fever what is viral illness what is viral infection what is virus fever what is yellow fever what temp is a fever what temperature is a fever what temperature is a fever for a baby what temperature is considered a fever what temperature is fever what to do for a fever what to do for fever what to do for high fever what to do when you have a fever what to do when your baby has a fever what to do with a fever what to take for a fever what to take for fever when does a fever become dangerous when is a fever dangerous when is a fever too high where in africa is ebola where in africa is ebola found where is ebola found in africa which is viral fever white plague who discovered lassa fever who lassa fever why infection causes fever www.dengue fever www.lassa fever xxx fever.in yellow fever yellow fever pictures yellow fever symptoms yellow fever treatment yellow fever virus yokohama yokohama lastik фивер шины lassa Lassa-Virus verursacht endemische und epidemische Krankheit in Nigeria, Guinea, Liberia und Sierra Leone, obwohl wahrscheinlich in einem viel größeren Bereich des westlichen Afrika auftreten. Lassa-Virus (wie andere Arenaviren) sind für die menschliche durch das Aerosol durch die chronisch infizierten Nagetieren emittiert übertragen. Die Infektion erfolgt während Fang und Verzehr dieser Tiere. Das Virus kann auch durch enge Kontakte zu verbreiten. Oft ist im Urin während der Erholungsphase, der Verdacht auf Samenflüssigkeit in den frühen Stadien einer Besserung vorhanden. Kranke Menschen aller Altersgruppen und beide Geschlechter. 1. FEVER LASSA - Epidemiologie Die Inzidenz ist am höchsten in der Trockenzeit, aber Infektionen ganze Jahr über auftreten. In Ländern, in denen Lassa-Virus endemisch ist, kann Lassa-Fieber eine dominante Anteil der fieberhaften Erkrankung sein. Zum Beispiel in Sierra Leone Labor bestätigt die Krankheit ist ständig auf 20% der Besucherzahlen auf Krankenhausstationen verantwortlich. Wahrscheinlich in Westafrika allein jedes Jahr gibt es Zehntausende von Fällen der Krankheit. 2. FEVER LASSA - Klinische Befunde unter ätiologischen Faktoren hämorrhagisches Fieber Arenaviren sind die einzige Ursache für die typischen fortschreitende Entwicklung der Krankheit. Häufig beobachtete einen allmählichen Beginn, mit dem Aufkommen von immer mehr schwere systemische Symptome. Blutungen ist nur etwa 15-30% der Fälle beobachtet. Patienten mit heller Haut kann oft plamistogrudkową Ausschlag zu sehen. Petechien sind häufig. Später, vor allem bei Männern, kann Perikarditis auftreten. Die Mortalitätsrate von Föten im letzten Trimester der Schwangerschaft ist 92%. Das Risiko der mütterlichen Todesfälle ist höher und beträgt 30% gegenüber 15% in der allgemeinen Bevölkerung der Patienten beobachtet. Diese Tatsachen könnten Ihnen empfehlen einen Schwangerschaftsabbruch in infizierten Frauen zu berücksichtigen. Leukozytenzahl normal oder leicht erhöht, und die Thrombozytenzahl normal ist oder leicht reduziert. Taubheit mit klinischer Besserung fällt in 20% der Fälle und ist langlebig. Bei einigen Patienten ist eine doppelseitige. Re-Infektion kann auftreten, aber ihren Verlauf ist in der Regel mild. 3. FEVER LASSA - Forschungslabor MEDICAL hohe Viruslast oder hoher Aktivität im Serum AST sind Prädiktoren für eine schlechte Prognose. Patienten mit Aspartat-Aminotransferase größer als 150 IU / mL sollten mit intravenösem Ribavirin behandelt werden. Es scheint, dass diese antiviralen Medikament (ein Nukleosid-Analogon) wirksam bei der Verringerung Sterblichkeit, die eine retrospektive kontrollierte Studien zeigen, gescheitert ist. Seine einzige nennenswerte Nebenwirkung ist reversibel Anämie, die in der Regel nicht eine Bluttransfusion erforderlich. Das Medikament durch langsame intravenöse Infusion in einer Dosis von 32 mg / kg verabreicht werden sollen; dann 16mg / kg alle 6 Stunden für 4 Tage, dann 8 mg / kg alle acht Stunden für 6 Tage. KATEGORIE: Infektionskrankheiten, MARITIME und Tropenmedizin, Mikrobiologie Virus Lassa provoque des maladies endémiques et épidémiques au Nigeria, la Guinée, le Libéria et la Sierra Leone, bien que susceptible de se produire sur une plus grande zone de l'Afrique de l'Ouest. Virus Lassa (comme d'autres arénavirus) sont transférés à l'homme à travers l'aérosol émis par les rongeurs infectés de manière chronique. L'infection se produit pendant la capture et la consommation de ces animaux. Le virus peut également se propager par des contacts étroits. Souvent, est présente dans l'urine au cours de la période de récupération, de la présence suspectée de liquide séminal dans les premiers stades de la reprise. Les personnes malades de tous âges et des deux sexes. 1. La fièvre de Lassa - Épidémiologie L'incidence est la plus élevée dans la saison sèche, mais les infections se produisent tout au long de l'année. Dans les pays où le virus de Lassa est endémique, la fièvre de Lassa peut être une proportion dominante de maladie fébrile. Par exemple, dans le laboratoire de la Sierra Leone a confirmé la maladie est constamment responsable de 20% des admissions dans les services hospitaliers. Probablement en Afrique de l'Ouest seul chaque année il ya des dizaines de milliers de cas de la maladie. 2. La fièvre de Lassa - Les résultats cliniques entre les facteurs étiologiques arénavirus de la fièvre hémorragique sont la seule cause du développement progressif typique de la maladie. Foire observé une apparition progressive, avec l'émergence de symptômes de plus en plus graves systémiques. Saignement est observé seulement environ 15-30% des cas. Les patients ayant la peau claire peuvent souvent être vus éruption plamistogrudkową. Pétéchies sont communs. Plus tard, la plupart du temps chez les hommes, peuvent se produire péricardite. Le taux de mortalité des foetus dans le dernier trimestre de la grossesse est de 92%. Le risque de mortalité maternelle est également plus élevé, et est de 30% contre 15% observé dans la population générale de patients. Ces faits peuvent suggérer d'envisager une interruption de grossesse chez les femmes infectées. Nombre de globules blancs dans le sang est normale ou légèrement élevée, et le taux de plaquettes est normale ou légèrement réduite. Surdité coïncide avec une amélioration clinique dans 20% des cas et est durable. Chez certains patients, est un double face. Re-infection peut se produire, mais son cours est généralement bénigne. 3. la fièvre de Lassa - LABORATOIRE DE RECHERCHE, charge virale élevée médical ou une forte activité dans l'AST sont des facteurs prédictifs de mauvais pronostic. Les patients atteints de l'aspartate aminotransférase supérieure à 150 UI / ml doivent être traités avec la ribavirine par voie intraveineuse. Il semble que ce médicament antiviral (un analogue nucléosidique) est efficace pour réduire les taux de mortalité, qui a échoué à démontrer une rétrospective des études contrôlées. Son seul effet significatif est l'anémie réversible, qui ne nécessite habituellement pas d'une transfusion sanguine. Le médicament doit être administré par perfusion intraveineuse lente à une dose de 32 mg / kg; puis 16 mg / kg toutes les 6 heures pendant 4 jours, puis 8 mg / kg toutes les huit heures pendant 6 jours. CATÉGORIE: les maladies infectieuses, maritime et de médecine tropicale, de la microbiologie Virus de Lassa causa la enfermedad endémica y epidémica en Nigeria, Guinea, Liberia y Sierra Leona, aunque es probable que se produzca en un área mucho más grande de África occidental. Virus Lassa (como otros arenavirus) se transfieren a humano a través del aerosol emitida por los roedores infectados crónicamente. La infección se produce durante la captura y el consumo de estos animales. El virus también puede propagarse a través de los contactos cercanos. A menudo está presente en la orina durante el período de recuperación, la sospecha de la presencia de líquido seminal en las primeras etapas de recuperación. Los enfermos de todas las edades y de ambos sexos. 1. fiebre de Lassa - EPIDEMIOLOGÍA La incidencia es más alta en la estación seca, pero las infecciones se producen durante todo el año. En los países donde el virus de Lassa es endémica, la fiebre de Lassa puede ser una proporción dominante de enfermedades febriles. Por ejemplo, en Sierra Leona laboratorio confirmó la enfermedad es siempre responsable del 20% de las admisiones a las salas del hospital. Probablemente en el África occidental solos cada año hay decenas de miles de casos de la enfermedad. 2. fiebre de Lassa - Hallazgos clínicos entre los factores etiológicos arenavirus fiebre hemorrágicas son la única causa del desarrollo progresivo típico de la enfermedad. Observa con frecuencia un comienzo gradual, con la aparición de más y más graves los síntomas sistémicos. El sangrado se observa sólo el 15-30% de los casos. Los pacientes con piel clara a menudo se pueden ver erupción plamistogrudkową. Las petequias son comunes. Más tarde, principalmente en los hombres, se puede producir pericarditis. La tasa de mortalidad de fetos en el último trimestre del embarazo es del 92%. El riesgo de mortalidad materna es también más alto, y es del 30% frente al 15% observado en la población general de pacientes. Estos hechos pueden sugerir a considerar la interrupción del embarazo en las mujeres infectadas. Conteo de glóbulos blancos es normal o ligeramente elevada, y el recuento de plaquetas es normal o ligeramente reducida. Sordera coincide con la mejoría clínica en el 20% de los casos y es durable. En algunos pacientes, es una doble cara. Puede ocurrir infección Re, pero su curso es generalmente leve. 3. la fiebre de Lassa - LABORATORIO DE INVESTIGACIÓN, carga viral alta médica o alta actividad en AST sérica son predictores de mal pronóstico. Los pacientes con aspartato aminotransferasa mayor que 150 UI / ml deben ser tratados con ribavirina intravenosa. Parece que este fármaco antiviral (un análogo de nucleósido) es eficaz en la reducción de las tasas de mortalidad, que no lograron demostrar un estudios retrospectivos controlados. Su único efecto secundario significativo es la anemia reversible, que por lo general no requiere de una transfusión de sangre. El medicamento debe ser administrado por infusión intravenosa lenta a una dosis de 32 mg / kg; luego 16 mg / kg cada 6 horas durante 4 días, luego de 8 mg / kg cada ocho horas durante 6 días. CATEGORÍA: ENFERMEDADES INFECCIOSAS, MARÍTIMO Y MEDICINA TROPICAL, Microbiología Вирус Ласса вызывает эндемический и эпидемические заболевания в Нигерии, Гвинее, Либерии и Сьерра-Леоне, хотя, скорее всего, происходят на гораздо большей площади Западной Африке. Вирус Ласса (как и другие аренавирусов) передаются человеку через аэрозоля, испускаемого хронически инфицированных грызунов. Заражение происходит во время ловли и едят этих животных. Вирус может также распространяться через тесные контакты. Часто присутствует в моче в течение периода восстановления, предположительное присутствие семенной жидкости на ранних стадиях восстановления. Больные люди всех возрастов и обоих полов. 1. ЛИХОРАДКА Ласса - ЭПИДЕМИОЛОГИЯ Заболеваемость наиболее высока в сухой сезон, но инфекции происходят в течение всего года. В странах, где вирус Ласса является эндемическим, лихорадки Ласса может быть доминирующим доля лихорадочного заболевания. Например, в Сьерра-Леоне лаборатории подтвердили заболевание постоянно отвечает за 20% от поступлений в больничных палатах. Вероятно, в Западной Африке в одиночку каждый год есть десятки тысяч случаев заболевания. 2. ЛИХОРАДКА Ласса - Клинические проявления среди этиологических факторов геморрагические аренавирусов лихорадка являются единственной причиной типичного прогрессивного развития заболевания. Часто наблюдается постепенное начало, с появлением все более и более тяжелых системных симптомов. Кровотечение наблюдается лишь около 15-30% случаев. Пациенты со светлой кожей, часто можно увидеть plamistogrudkową сыпь. Петехии являются общими. Позже, в основном у мужчин, может возникнуть перикардит. Смертность плодов в последнем триместре беременности составляет 92%. Риск материнской смертности также выше, и составляет 30% против 15% наблюдается в общей популяции пациентов. Эти факты могут предложить рассмотреть прерывания беременности у инфицированных женщин. Лейкоцитов в крови нормальное или слегка повышенной, и количество тромбоцитов в норме или немного уменьшается. Глухота совпадает с клиническим улучшением в 20% случаев и является прочным. У некоторых пациентов, является двухсторонняя. Re-инфекции может произойти, но его, конечно, как правило, мягкая. 3. ЛИХОРАДКА Ласса - ЛАБОРАТОРИЯ, МЕДИЦИНСКИЙ высокая вирусная нагрузка или высокая активность в сыворотке АСТ являются прогностическими факторами плохого прогноза. Пациенты с аспартатаминотрансферазы более 150 МЕ / мл, следует относиться с внутривенного рибавирином. Кажется, что это противовирусный препарат (аналог нуклеозидов) является эффективным в снижении смертности, которые не смогли продемонстрировать ретроспективу контролируемых исследований. Его единственным существенным побочным эффектом является обратимым анемия, которая обычно не требует переливания крови. Препарат следует вводить путем медленной внутривенной инфузии в дозе 32 мг / кг; затем 16 мг / кг каждые 6 часов в течение 4 дней, затем 8 мг / кг каждые восемь часов в течение 6 дней. КАТЕГОРИИ: инфекционные заболевания, МОРСКОЙ и тропической медицины, микробиологии