NIEDOBÓR CYNKU (ang. ZINC DEFICIENCY)

Niedobór cynku niewielkiego stopnia obserwuje się w wielu schorzeniach - w cukrzycy, zakażeniu wirusem HIV (oraz AIDS), marskości wątroby, alkoholizmie, chorobach zapalnych jelit, przy zaburzeniach wchłaniania oraz anemii sierpowatokrwinkowej. Niewielki spadek poziomu cynku może wystąpić w ciąży oraz w czasie przyjmowania leków antykoncepcyjnych. Również hipoalbuminemia, niezależnie od jej przyczyny, pociąga za sobą spadek poziomu Zn w surowicy krwi. U pacjentów z chorobą Wilsona mogą wystąpić objawy niedoboru cynku w trakcie leczenia penicylaminą. W sytuacji nagłego stresu cynk jest transportowany z krwi do tkanek. Najczęściej współistnieje niedobór innych mikroelementów, zwłaszcza żelaza. 

1. NIEDOBÓR CYNKU - DEFINICJA (NORMA LABORATORYJNA)

Niedobór cynku stwierdza się, jeśli jego stężenie w surowicy krwi jest mniejsze od 12 mikromoli w litrze (< 12 µmol/l), co odpowiada 70 mikrogramom w decylitrze (< 70 µg/dl). 

2. NIEDOBÓR CYNKU - OBJAWY KLINICZNE

Niedobór cynku wiąże się z występowaniem zaburzeń wzrostu u dzieci, hipogeuzją (osłabieniem smaku) oraz upośledzeniem funkcji układu odpornościowego. Znaczny i długotrwały niedobór cynku jest przyczyną hipogonadyzmu, niskorosłości oraz zaburzeń pigmentacji włosów u dzieci (zwłaszcza w niektórych krajach Bliskiego Wschodu). Niedobór cynku często występuje w krajach rozwijających się.

3. NIEDOBÓR CYNKU - WRODZONY NIEDOBÓR CYNKU

Nieprawidłowe wchłanianie cynku występuje w acrodermatitis enteropatica - rzadkiej chorobie wrodzonej, dziedziczonej w sposób autosomalny recesywny (zespół Brandta lub zespół Danbolta-Clossa). Jej objawy to:

• biegunka,
• łysienie,
• zanik mięśni,
• depresja,
• drażliwość,
• wysypka w obrębie kończyn, twarzy i krocza.

Wykwity mają charakter pęcherzyków i krost, z tendencją do tworzenia strupów, łuszczenia się i powstawania rumienia. 


4. NIEDOBÓR CYNKU - LECZENIE

W przypadku niedoboru podaje się 60 mg cynku (w przeliczeniu na pierwiastek) doustnie, 2 razy dziennie. Tabletki glukonianu cynku (zawierające 13 mg czystego cynku, stosowane co 2 godziny od chwili przebudzenia) mają łagodzić przebieg i skracać czas trwania infekcji wirusowych u dorosłych. Cynk (20 mg dziennie) jest stosowany jako leczenie wspomagające u dzieci podczas biegunki.

Po doustnym podaniu cynku mogą pojawić się ostre objawy - nudności, wymioty i gorączka. Długotrwałe przyjmowanie dużych ilości cynku może prowadzić do osłabienia odporności organizmu oraz rozwoju niedokrwistości niedobarwliwej z powodu niedoboru miedzi. 

W tym miejscu jako ciekawostkę należy również wspomnieć, że opary powstające podczas spawania cynku są toksyczne i wywołują ponadto niewydolność oddechową, nadmierne wydzielanie śliny, pocenie i bóle głowy. 

KATEGORIA: BIOCHEMIA KLINICZNA, DIETETYKA, PEDIATRIA, NEONATOLOGIA, CHOROBY WEWNĘTRZNE

TAGI: Bei vielen Krankheiten beobachtet milde Zinkmangel - Diabetes, HIV-Infektion (AIDS), Leberzirrhose, Alkoholismus, entzündlicher Darmerkrankung, Störungen der Absorption, und Sichelzellenanämie. Der leichte Rückgang in der Höhe von Zink kann in der Schwangerschaft oder während der Einnahme von oralen Kontrazeptiva auftreten. Auch, Hypalbuminämie, unabhängig von deren Ursachen, notwendigerweise eine Reduzierung des Niveaus der Zn im Blutserum. Bei Patienten mit Morbus Wilson können Symptome von Zinkmangel während der Behandlung mit Penicillamin haben. Im Falle einer plötzlichen Belastung Zink wird aus dem Blut in das Gewebe transportiert werden. Die meisten koexistieren Mangel an anderen Spurenelemente , insbesondere Eisen. 1 Mangel an Zink - Definition (Standard-Labor) Zinkmangelzuständen, wenn seine Konzentration im Blutserum weniger als 12 Mikromol pro Liter (<12 mmol / l), die mit 70 Mikrogramm in decylitrze entspricht, ist (<70 mg / dl). 2 Mangel an Zink - klinische Zeichen Zinkmangel wird mit Wachstumsstörungen bei Kindern, hipogeuzją (Schwächung der Geschmack) und die Beeinträchtigung der Immunfunktion . Eine signifikante und anhaltende Zinkmangel ist die Ursache des Hypogonadismus, Kleinwuchs und Haarpigmentstörungen bei Kindern (vor allem in einigen Ländern des Nahen Ostens). Zinkmangel ist in Entwicklungsländern weit verbreitet. 3 Mangel an Zink - erblichen Mangel an Zink Malabsorption von Zink tritt in Acrodermatitis enteropatica - eine seltene angeborene Erkrankung, erbte in autosomal-rezessiv (Brandt-Syndrom oder Syndrom Danbolta-Closs). Zu den Symptomen zählen Durchfall, Haarausfall, Muskelschwund, Depressionen, Reizbarkeit, Hautausschlag an den Extremitäten, Gesicht und im Schritt. Ausbrüche sind Bläschen und Pusteln, mit einer Tendenz zur Krustenbildung, Schuppung, und die Bildung von Erythem. 4 Zinkmangel - aber im Falle eines Mangels verabreicht 60 mg Zink (ausgedrückt als Element) oral zweimal täglich. Zinkgluconattabletten (mit 13 mg reinem Zink, angewendet alle zwei Stunden von der Zeit des Erwachens), um Verfahren zu erleichtern und verkürzen die Dauer von viralen Infektionen bei Erwachsenen. Zink (20 mg täglich) als Zusatztherapie bei Kindern bei Durchfall eingesetzt. Übelkeit, Erbrechen und Fieber - nach oraler Gabe von Zink kann akut auftreten. Langfristige Einnahme von großen Mengen an Zink kann zu einer Schwächung des körpereigenen Widerstandsfähigkeit und die Entwicklung von hypochromen Anämie durch Kupfermangel führen. An diesem Punkt, als Kuriosität sollte auch erwähnen, dass die beim Schweißen von Zink erzeugten Abgase sind giftig und verursachen Atemversagen, zudem übermäßiger Speichelfluss, Schwitzen und Kopfschmerzen. KATEGORIE: Klinische Biochemie, Ernährung, Kinderheilkunde, Neonatologie, Krankheiten Innere Mild zinc deficiency observed in many diseases - diabetes, HIV infection (and AIDS), liver cirrhosis, alcoholism, inflammatory bowel disease, disorders of absorption, and sickle cell anemia. The slight decrease in the level of zinc may occur in pregnancy or while taking oral contraceptives. Also, hypoalbuminemia, regardless of its cause, entail a drop in the level of Zn in blood serum. In patients with Wilson's disease may have symptoms of zinc deficiency during treatment with penicillamine. In the event of sudden stress zinc is transported from the blood into tissues. Most coexist deficiency of other trace elements, in particular iron. 1 DEFICIENCY OF ZINC - DEFINITION (STANDARD LABORATORY) Zinc deficiency states, if its concentration in the blood serum is less than 12 micromoles per liter (<12 mmol / l), which corresponds to 70 micrograms in decylitrze (<70 mg / dl). 2 DEFICIENCY OF ZINC - CLINICAL SIGNS Zinc deficiency is associated with growth failure in children, hipogeuzją (weakening of taste), and impaired immune function. A significant and prolonged zinc deficiency is the cause of hypogonadism, short stature and hair pigmentation disorders in children (especially in some countries of the Middle East). Zinc deficiency is common in developing countries. 3 DEFICIENCY OF ZINC - hereditary deficiency of zinc malabsorption of zinc occurs in acrodermatitis enteropatica - a rare congenital disease, inherited in an autosomal recessive manner (Brandt syndrome or syndrome Danbolta-Closs). Its symptoms include diarrhea, hair loss, muscle atrophy, depression, irritability, rash on the extremities, face and crotch. Eruptions are vesicles and pustules, with a tendency to crusting, flaking, and the formation of erythema. 4 Zinc deficiency - but in the case of a shortage administered 60 mg of zinc (expressed as element) orally two times a day. Zinc gluconate tablets (containing 13 mg of pure zinc, applied every two hours from the time of awakening) to ease process and shorten the duration of viral infections in adults. Zinc (20 mg daily) is used as adjunctive therapy in children during diarrhea. After oral administration of zinc may occur acute - nausea, vomiting and fever. Long-term intake of large amounts of zinc can lead to a weakening of the body's resistance and the development of hypochromic anemia due to copper deficiency. At this point, as a curiosity should also mention that the fumes generated during welding of zinc are toxic and cause respiratory failure, moreover, excessive salivation, sweating and headaches. CATEGORY: CLINICAL BIOCHEMISTRY, NUTRITION, PEDIATRICS, Neonatology, DISEASES INTERNAL Légère carence en zinc observée dans de nombreuses maladies - diabète, l'infection par le VIH (SIDA), la cirrhose du foie, l'alcoolisme, une maladie intestinale inflammatoire, des troubles de l'absorption, et l'anémie à hématies falciformes. La légère diminution du niveau de zinc peut se produire pendant la grossesse ou lors de la prise de contraceptifs oraux. Aussi, hypoalbuminémie, quelle que soit sa cause, entraînent une baisse du niveau de zinc dans le sérum sanguin. Chez les patients atteints de la maladie de Wilson peut avoir des symptômes de carence en zinc pendant le traitement par la pénicillamine. En cas de coup de stress zinc est transporté à partir du sang dans les tissus. La plupart carence coexistent d'autres oligo-éléments, en particulier du fer. 1 carence en zinc - DÉFINITION (STANDARD DE LABORATOIRE) Zinc états de carence, si sa concentration dans le sérum sanguin est inférieur à 12 micromoles par litre (<12 mmol / l), ce qui correspond à 70 microgrammes dans decylitrze (<70 mg / dl). 2 carence en zinc - SIGNES CLINIQUES La carence en zinc est associée à un retard de croissance chez les enfants, hipogeuzją (affaiblissement du goût), et la fonction immunitaire altérée. Une carence importante et prolongée de zinc est la cause de l'hypogonadisme, la petite taille et la pigmentation des cheveux troubles chez les enfants (en particulier dans certains pays du Moyen-Orient). La carence en zinc est fréquente dans les pays en développement. 3 carence en zinc - déficit héréditaire de la malabsorption de zinc de zinc se produit dans l'acrodermatite entéropathique - une maladie congénitale rare, transmise selon le mode autosomique récessif (syndrome Brandt ou syndrome Danbolta-Closs). Ses symptômes incluent la diarrhée, la perte de cheveux, l'atrophie musculaire, la dépression, l'irritabilité, une éruption cutanée sur les extrémités, le visage et à l'entrejambe. Les éruptions sont des vésicules et des pustules, avec une tendance à la formation de croûtes, desquamation, et la formation d'un érythème. 4 carence en zinc - mais dans le cas d'un manque administré 60 mg de zinc (exprimé en élément) par voie orale deux fois par jour. Comprimés de zinc gluconate (contenant 13 mg de zinc pur, appliquées toutes les deux heures à partir du moment de l'éveil) pour améliorer le processus et de raccourcir la durée des infections virales chez les adultes. Zinc (20 mg par jour) est utilisée comme traitement adjuvant chez les enfants pendant la diarrhée. Après administration orale de zinc peut se produire aiguë - nausées, des vomissements et de la fièvre. Prise à long terme de grandes quantités de zinc peut conduire à un affaiblissement de la résistance de l'organisme et le développement de l'anémie hypochrome due à une carence en cuivre. À ce stade, comme une curiosité devrait également mentionner que les fumées générées lors du soudage de zinc sont toxiques et provoquent une insuffisance respiratoire, d'ailleurs, une salivation excessive, des sueurs et des maux de tête. CATÉGORIE: biochimie clinique, NUTRITION, pédiatrie, néonatologie, maladies internes La deficiencia leve de zinc observado en muchas enfermedades - diabetes, infección por VIH (SIDA), cirrosis hepática, alcoholismo, enfermedad inflamatoria del intestino, trastornos de la absorción, y la anemia de células falciformes. La ligera disminución en el nivel de zinc puede ocurrir durante el embarazo o mientras está tomando anticonceptivos orales. Además, hipoalbuminemia, independientemente de su causa, implica una caída en el nivel de Zn en el suero sanguíneo. En los pacientes con enfermedad de Wilson puede tener síntomas de la deficiencia de zinc durante el tratamiento con penicilamina. En el caso de zinc estrés repentino se transporta desde la sangre hacia los tejidos. La mayor deficiencia coexisten de otros elementos traza, especialmente hierro. 1 DEFICIENCIA DE ZINC - DEFINICIÓN estados carenciales (estándar de laboratorio) de zinc, si su concentración en el suero de la sangre es inferior a 12 micromoles por litro (<12 mmol / l), lo que corresponde a 70 microgramos en decylitrze (<70 mg / dl). 2 DEFICIENCIA DE ZINC - SIGNOS CLÍNICOS La deficiencia de zinc se asocia con retraso del crecimiento en niños, hipogeuzją (debilitamiento del gusto), y la función inmunológica alterada. Una deficiencia significativa y prolongada de zinc es la causa de los trastornos de hipogonadismo, baja estatura y de pigmentación del cabello en los niños (especialmente en algunos países de Oriente Medio). La deficiencia de zinc es común en países en desarrollo. 3 DEFICIENCIA DE ZINC - deficiencia hereditaria de la mala absorción de zinc de zinc se produce en la acrodermatitis enteropática - una enfermedad congénita rara, hereda de forma autosómica recesiva (síndrome Brandt o síndrome Danbolta-Closs). Sus síntomas incluyen diarrea, pérdida de cabello, atrofia muscular, depresión, irritabilidad, erupción en las extremidades, la cara y la entrepierna. Las erupciones son vesículas y pústulas, con tendencia a la formación de costras, descamación, y la formación de eritema. 4 La deficiencia de zinc - pero en el caso de una escasez administrado 60 mg de zinc (expresado como elemento) por vía oral dos veces al día. Tabletas de gluconato de cinc (que contiene 13 mg de zinc puro, aplicados cada dos horas desde el momento de despertar) para facilitar el proceso y acortar la duración de las infecciones virales en los adultos. Zinc (20 mg al día) se utiliza como terapia adyuvante en los niños durante la diarrea. Después de la administración oral de zinc puede producir aguda - náuseas, vómitos y fiebre. El consumo a largo plazo de grandes cantidades de zinc puede conducir a un debilitamiento de la resistencia del cuerpo y el desarrollo de anemia hipocrómica debido a la deficiencia de cobre. En este punto, como una curiosidad También debería mencionar que los humos generados durante la soldadura de zinc son tóxicos y causan insuficiencia respiratoria, por otra parte, salivación excesiva, sudoración y dolor de cabeza. CATEGORÍA: Bioquímica Clínica, NUTRICION, pediatría, neonatología, medicina interna Мягкий дефицит цинка наблюдается при многих заболеваниях - сахарный диабет, ВИЧ-инфекции (СПИД), цирроз печени, алкоголизм, воспалительное заболевание кишечника, нарушения абсорбции, и серповидно-клеточной анемии. Незначительное снижение уровня цинка может произойти во время беременности или во время приема оральных контрацептивов. Кроме того, гипоальбуминемии, независимо от причины, влечет за собой снижение уровня Zn в сыворотке крови. У пациентов с болезнью Вильсона может иметь симптомы дефицита цинка во время лечения с пеницилламин. В случае внезапного стресса цинка транспортируется из крови в ткани. Наиболее сосуществуют дефицит других микроэлементов, в частности железа. 1 Дефицит цинка - Определение состояния дефицита (стандартных лабораторных) Цинк, если его концентрация в сыворотке крови меньше 12 мкмоль на литр (<12 ммоль / л), что соответствует 70 мкг в decylitrze (<70 мг / дл). 2 Дефицит цинка - клинические признаки Дефицит цинка связана с недостаточностью роста у детей, hipogeuzją (ослабления вкуса), и нарушения иммунной функции. Значительное и длительное дефицит цинка является причиной гипогонадизм, низкорослость и волосы пигментации расстройств у детей (особенно в некоторых странах Ближнего Востока). Дефицит цинка часто встречается в развивающихся странах. 3 Дефицит цинка - наследственным дефицитом цинка всасывания цинка происходит в акродерматит enteropatica - редкое врожденное заболевание, наследуется по аутосомно-рецессивному типу (синдром Brandt или синдром Danbolta-Клосс). Его симптомы включают диарею, потерю волос, мышечную атрофию, депрессия, раздражительность, сыпь на конечностях, лице и промежности. Извержения являются пузырьки и пустулы, с тенденцией к корки, шелушение, и формирование эритемы. Дефицит цинка 4 -, но в случае нехватки вводили 60 мг цинка (выраженные в виде элемента) перорально два раза в день. Цинк глюконат таблетки (содержащие 13 мг чистого цинка, применяется каждые два часа с момента пробуждения), чтобы облегчить процесс и сократить продолжительность вирусных инфекций у взрослых. Цинк (20 мг в день) используется в качестве дополнительной терапии у детей во время диареи. После приема внутрь цинка может осуществляться острый - тошнота, рвота и лихорадка. Долгосрочное потребление больших количеств цинка может привести к ослаблению сопротивляемости организма и развитием гипохромной анемии вследствие дефицита меди. В этот момент, как любопытство должен также упомянуть, что пары, образующиеся при сварке цинка токсичны и вызывают дыхательную недостаточность, кроме того, повышенное слюноотделение, потливость и головные боли. 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