POLEKOWE CHOROBY PAZNOKCI (ang. DRUG-INDUCED NAIL DISEASES)

<div class="separator" style="clear: both; text-align: center;"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjidMYulIXteLx91pfJjiIpEooTTzXks2SwGhIycK0bpLP5nyqRCmz93og3HM9Odgb2Aibh6o_c3cVOjWrG-1S7D5XU9gTdTet5Ek3Wd7AYvXL2fUaxUXhuJXZT4RHGv9jr7OV50g6r3TU/s1600/paznokci.jpg" imageanchor="1" style="clear: left; float: left; margin-bottom: 1em; margin-right: 1em;"><img border="0" height="138" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEjidMYulIXteLx91pfJjiIpEooTTzXks2SwGhIycK0bpLP5nyqRCmz93og3HM9Odgb2Aibh6o_c3cVOjWrG-1S7D5XU9gTdTet5Ek3Wd7AYvXL2fUaxUXhuJXZT4RHGv9jr7OV50g6r3TU/s1600/paznokci.jpg" width="200" /></a></div> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="background-color: white; font-size: 14px; line-height: 19.600000381469727px;"><b>Zmiany chorobowe paznokci spowodowane stosowaniem niektórych leków zazwyczaj pojawiają się w obrębie kilku z nich (rzadziej natomiast obejmują wszystkie) i potrzeba dość długiego okresu czasu (zwykle kilku miesięcy), by ustąpiły po odstawieniu wywołującego je farmaceutyku. Patomechanizm tych uszkodzeń wiąże się z toksycznością w stosunku do komórek macierzy paznokcia stosowanej substancji farmakologicznej. Poniżej zostanie scharakteryzowane kilka najczęściej występujących zmian patologicznych w obrębie paznokci wywołanych przez leki.</b></span></span><br /> <b style="color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><br /></b> <span style="text-align: justify;"><br /></span><br /> <div style="text-align: start;"> <b style="color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bold; line-height: 19.600000381469727px;">1. </b><span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14px; line-height: 19.600000381469727px;"><b>POLEKOWE CHOROBY PAZNOKCI - EPIDEMIOLOGIA</b></span></span></div> <div style="font-weight: bold; text-align: start;"> <span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; font-weight: normal; line-height: 19.600000381469727px; text-align: justify;"><br /></span></div> <div style="text-align: start;"> <span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;">Najczęściej występującymi polekowymi schorzeniami paznokci są:</span><br /> <span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><br /></span> <br /> <ul> <li><span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><b>linie Beau</b> - poprzeczne zagłębienia płytek paznokciowych,</span></li> <li><span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><b>onycholiza</b> - odklejenie dystalnej części płytki paznokciowej od łożyska,</span></li> <li><span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><b>onychomadeza</b> - odklejenie proksymalnej części płytki paznokciiowej od łożyska,</span></li> <li><span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><b>paronychia</b> - zmiany zapalne skóry otaczającej paznokieć,</span></li> <li><span style="background-color: white; color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px; text-align: justify;"><b>przebarwienia</b>.</span></li> </ul> </div> <br /> <br /> <div> <div style="background-color: white;"> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14px; line-height: 19.600000381469727px;"><b>2. </b></span></span><b style="color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px;"> </b><span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14px; line-height: 19.600000381469727px;"><b>POLEKOWE CHOROBY PAZNOKCI - CHARAKTERYSTYKA</b></span></span></div> <div style="background-color: white;"> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif; font-size: 14px; line-height: 19.600000381469727px;"><br /></span><span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14.44444465637207px; line-height: 19.600000381469727px;"><b>Onycholiza</b> może rozwinąć się w następstwie reakcji fototoksycznych, głównie w przypadku przyjmowania tetracyklin, fluorochinolonów, pochodnych fenotiazyny i psolarenów, ale również podczas stosowania niesteroidowych leków przeciwzapalnych (NLPZ), kaptoprylu, retinoidów, walproinianu sodu i wielu chemioterapeutyków takich jak taksany (paklitaksel, docetaksel) i antracykliny. Ryzyko wystąpienia onycholizy u pacjentów przyjmujących leki cytotoksyczne rośnie pod wpływem ekspozycji na promienie słoneczne.<br /><br /><b>Onychomadezę</b> wywołuje czasowe wstrzymanie aktywności mitotycznej macierzy paznokcia. DO leków wywołujących to zaburzenie należy karbamazepina, lit, retinoidy oraz takie chemioterapeutyki jak winkrystyna i cyklofosfamid.</span></span><br /> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14.44444465637207px; line-height: 19.600000381469727px;"><br /></span></span> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14.44444465637207px; line-height: 19.600000381469727px;"><b>Paronychia</b>, jak również <b>mnogi ziarniniak ropotwórczy</b> (przebiegający z tworzeniem bolesnych okołopaznokciowych ropni na palcach rąk i stóp) są ubocznym efektem ogólnego stosowania retinoidów, lamiwudyny, indinawiru, monoklonalnych przeciwciał anty-EGFR (cetuximab, gefitinib).</span></span><br /> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14.44444465637207px; line-height: 19.600000381469727px;"><br /></span></span> <span style="color: #222222; font-family: Arial, Helvetica, sans-serif;"><span style="font-size: 14.44444465637207px; line-height: 19.600000381469727px;"><b>Zmiana koloru paznokci</b> spowodowana przez leki takie jak antracykliny, taksany, fluorouracyl i zydowudyna spowodowana jest przebarwieniem łożyska paznokcia w następstwie stymulacji melanocytów. Efekt ten jest całkowicie odwracalny, a jego nasilenie zależy od dawki leku. </span></span><br /> <br /></div> <div style="background-color: white;"> <span style="font-family: Arial, Helvetica, sans-serif; font-size: 14px; font-weight: bolder; line-height: 19.600000381469727px; text-align: justify;">KATEGORIA: </span><span style="font-family: Arial, Helvetica, sans-serif; text-align: justify;"><span style="font-size: 14px; line-height: 19.600000381469727px;">DERMATOLOGIA, FARMAKOLOGIA KLINICZNA, MEDYCYNA ESTETYCZNA</span></span></div> </div> <center> <iframe allowfullscreen="" frameborder="0" height="315" src="//www.youtube.com/embed/uHFRpvBJabs?autoplay=1" width="420"></iframe></center> <div style="margin: 0px; outline: none; padding: 0px; text-align: justify;"> <span style="color: white;"><span style="background-color: white;"><span style="font-family: Arial, Tahoma, Helvetica, FreeSans, sans-serif; font-size: xx-small; line-height: 18.479999542236328px;"><span style="outline: none;"><span style="line-height: 19.600000381469727px;"><span style="font-family: Arial, Helvetica, sans-serif;">TAGI: </span></span></span></span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">Nail lesions caused by the use of certain drugs usually appear within a few of them (less frequently include all) and the need for a fairly long period of time (usually several months), that resolved after discontinuation of causative pharmaceutical. Pathomechanism of these lesions associated with toxicity to the cells of the nail matrix, the pharmacological substance used. Below is characterized some of the most common pathological changes in the nail caused by drugs. 1 Drug-induced NAIL DISEASES - EPIDEMIOLOGY The most common nail disease prodrug are: Beau lines - transverse depressions nail plates, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">onycholysis - detachment of the distal nail plate from the bearing, </span></span><br /> <span style="color: white;"><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">onychomadeza - detachment of the proximal portion of the plate paznokciiowej of bearings, paronychia - inflammation of the skin surrounding the nail, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">discoloration. 2 Drug-induced NAIL DISEASES - FEATURES </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">Onycholysis may develop as a result of phototoxic reaction, especially when taking tetracyclines, fluoroquinolones, phenothiazines and psolarenów, but also during the use of nonsteroidal anti-inflammatory drugs (NSAIDs), captopril, retinoids, sodium valproate, and many chemotherapeutic agents such as taxanes (paclitaxel, docetaxel) and anthracyclines. The risk of onycholizy in patients receiving cytotoxic drugs increases when exposed to sunlight. Onychomadezę causes temporary suspension of mitotic activity nail matrix. TO drugs known to cause this disorder must carbamazepine, lithium, retinoids and chemotherapeutic agents such as vincristine and cyclophosphamide. Paronychia, as well as pyogenic granuloma myeloma (running with the formation of painful periungual abscesses on the fingers and toes) are a side effect of general use of retinoids, lamivudine, indinavir, monoclonal anti-EGFR (cetuximab, gefitinib). Changing the color of the nail caused by drugs such as anthracyclines, taxanes, fluorouracil, and zidovudine is caused by discoloration of the nail as a result of stimulation of melanocytes. This effect is fully reversible, and the severity was dose related. CATEGORY: DERMATOLOGY, CLINICAL PHARMACOLOGY, MEDICINE AESTHETIC TAGS: </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">Nail поражения, вызванные использованием определенных препаратов обычно появляются в течение нескольких из них (реже включают все) и необходимости довольно длительного периода времени (обычно несколько месяцев), что решен после прекращения причинного фармацевтической. Патологическом этих поражений, связанных с токсичностью по отношению к клеткам ногтевой матрицы, фармакологическое вещество, используемое. Ниже характеризуется некоторые из наиболее распространенных патологических изменений в ногте, вызванных препаратов. 1 медикаментозный заболеваний ногтей - эпидемиология Самый распространенный пролекарство ногтей болезни являются: ​​Бо линии - поперечные впадины ногтевые пластины, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">онихолизис - отряд дистальной ногтевой пластины от подшипника, onychomadeza - отряд проксимальной части пластины paznokciiowej подшипников, Паронихия - воспаление кожи вокруг ногтя обесцвечивание. 2 медикаментозный заболеваний ногтей - DATA онихолизис может развиться в результате фототоксических реакций, особенно если вы принимаете тетрациклин, фторхинолонов, фенотиазины и psolarenów, но и использование нестероидных противовоспалительных препаратов (НПВП), каптоприл, ретиноиды, вальпроата натрия, и многих химиотерапевтических агентов таких а таксанов (паклитаксела, доцетаксела), и антрациклинов. Риск onycholizy у пациентов, получающих цитотоксические препараты повышают при воздействии солнечного света. Onychomadezę вызывает временную приостановку митотической активности ногтей матрицы. К наркотиков, вызывающих это заболевание должно карбамазепин, литий, ретиноиды и химиотерапевтических агентов, таких как винкристин и циклофосфамид. Паронихия, а также гнойные гранулемы миелома (работает с образованием болезненных Periungual абсцессов на пальцах рук и ног) являются побочным эффектом общего пользования ретиноиды, ламивудин, индинавиром, моноклональное анти-EGFR (цетуксимаб, гефитинибом). Изменение цвета ногтей, вызванной лекарствами, такими как антрациклины, таксаны, фторурацил, зидовудин и обусловлено изменение цвета ногтя в результате стимуляции меланоцитов. Этот эффект полностью обратим, и тяжесть была доза связаны между собой. КАТЕГОРИИ: дерматология, клиническая фармакология, медицина ЭСТЕТИЧЕСКИЕ TAGS </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">Lesiones ungueales causadas por el uso de ciertos medicamentos suelen aparecer dentro de unos pocos de ellos (con menos frecuencia incluyen todos) y la necesidad de un período bastante largo de tiempo (generalmente varios meses), que se resolvió después de la interrupción de productos farmacéuticos causal. Mecanismo patológico de estas lesiones asociadas con toxicidad para las células de la matriz de la uña, la sustancia farmacológica utilizada. A continuación se caracteriza algunos de los cambios patológicos más comunes en las uñas causada por medicamentos. 1 inducidos por fármacos enfermedades de las uñas - EPIDEMIOLOGÍA El profármaco enfermedad de las uñas más comunes son: Líneas de Beau - depresiones transversales placas de la uña, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">onicolisis - desprendimiento de la placa de la uña distal del cojinete, onychomadeza - desprendimiento de la porción proximal de la placa paznokciiowej de cojinetes, paroniquia - inflamación de la piel que rodea a la decoloración de las uñas. 2 Enfermedades de la Uña inducidos por fármacos - onicólisis DATOS puede desarrollarse como resultado de las reacciones fototóxicas, especialmente si usted está tomando tetraciclinas, fluoroquinolonas, fenotiazinas y psolarenów, sino también el uso de medicamentos no esteroides antiinflamatorios (AINE), captopril, retinoides, valproato de sodio, y muchos agentes quimioterapéuticos tales como taxanos (paclitaxel, docetaxel), y antraciclinas. El riesgo de onycholizy en pacientes que reciben fármacos citotóxicos se incrementa cuando se expone a la luz solar. Onychomadezę provoca suspensión temporal de la actividad de la matriz de uñas mitótico. A los medicamentos que se sabe causan este trastorno debe carbamazepina, el litio, los retinoides y los agentes quimioterapéuticos como vincristina y ciclofosfamida. Paroniquia, así como mieloma granuloma piógeno (que se ejecuta con la formación de abscesos periungueales dolorosas en los dedos de manos y pies) son un efecto secundario del uso general de los retinoides, lamivudina, indinavir, monoclonal anti-EGFR (cetuximab, gefitinib). Cambiar el color de las uñas causada por fármacos tales como antraciclinas, taxanos, fluorouracilo y zidovudina es causada por la decoloración de la uña, como resultado de la estimulación de los melanocitos. Este efecto es totalmente reversible, y la gravedad de la dosis relacionada. CATEGORÍA: Dermatología, Farmacología Clínica, Medicina Estética TAGS: </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">Nagel Läsionen, die durch die Verwendung von bestimmten Medikamenten verursacht erscheinen in der Regel innerhalb ein paar von ihnen (weniger häufig enthalten alle) und die Notwendigkeit für eine ziemlich lange Zeit (in der Regel mehrere Monate), nach Absetzen der verursachenden Pharma, dass gelöst werden. Pathomechanismus dieser Läsionen mit Toxizität für die Zellen der Nagelmatrix zugeordnet ist, die pharmakologische Substanz verwendet wird. Nachstehend einige der häufigsten pathologischen Veränderungen des Nagels durch Medikamente verursacht wird. 1 Arzneimittel-induzierter Nagelerkrankungen - Epidemiologie Die häufigste Nagelerkrankung Prodrug sind: Beau Linien - Quer Depressionen Nagelplatten, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">onycholysis - Ablösung des distalen Nagelplatte vom Lager, onychomadeza - Ablösung der proximale Abschnitt der Platte paznokciiowej von Lagern, Paronychie - Entzündung der Haut rund um den Nagel verfärbt. 2 Arzneimittel-induzierter Nagelerkrankungen - DATEN onycholysis kann als Ergebnis der phototoxische Reaktionen zu entwickeln, vor allem wenn Sie Tetracycline, Fluorchinolone, Phenothiazine und psolarenów werden, sondern auch die Verwendung von nicht-steroidalen Antirheumatika (NSAIDs), Captopril, Retinoide, Valproinsäure und viele Chemotherapeutika wie wie Taxane (Paclitaxel, Docetaxel) und Anthracycline. Das Risiko von onycholizy bei Patienten, die Zytostatika erhöht sich, wenn es dem Sonnenlicht ausgesetzt. Onychomadezę verursacht vorübergehende Aussetzung der mitotische Aktivität Nagelmatrix. Zu Drogen bekannt, verursachen diese Störung muss Carbamazepin, Lithium, Retinoide und Chemotherapeutika wie Vincristin und Cyclophosphamid. Paronychia sowie pyogenes Granulom Myelom (läuft mit der Bildung von schmerzhaften periungual Abszessen an den Fingern und Zehen) sind ein Nebeneffekt der allgemeinen Verwendung von Retinoiden, Lamivudin, Indinavir, monoklonalen Anti-EGFR (Cetuximab, Gefitinib). Ändern der Farbe des Nagels durch Medikamente wie Anthrazykline, Taxane, Fluorouracil und Zidovudin verursacht durch Verfärbung des Nagels als Folge der Stimulation von Melanozyten verursacht. Dieser Effekt ist vollständig reversibel, und der Schweregrad war dosisabhängig. KATEGORIE: Dermatologie, Klinische Pharmakologie, MEDIZIN ÄSTHETISCHE TAGS: </span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small;"><span style="line-height: 19.600000381469727px;">Lésions des ongles causées par l'utilisation de certains médicaments apparaissent habituellement dans un peu d'entre eux (moins fréquemment comprennent tous) et la nécessité d'une assez longue période de temps (habituellement plusieurs mois), que résolus après l'arrêt du pharmaceutique causal. Mécanisme pathogénique de ces lésions associées à une toxicité pour les cellules de la matrice de l'ongle, la substance pharmacologique utilisé. Ci-dessous est caractérisé quelques-uns des changements pathologiques les plus courantes dans l'ongle causées par les médicaments. 1 induite par la drogue NAIL MALADIES - Epidémiologie Le promédicament de la maladie de l'ongle les plus courantes sont: les lignes de Beau - dépressions transversales plaques d'ongles, </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: xx-small; line-height: 19.600000381469727px;">onycholyse - détachement de la plaque de l'ongle distale du palier, onychomadeza - détachement de la partie proximale de la paznokciiowej de plaque de roulements, panaris - inflammation de la peau autour de la décoloration des ongles. 2 maladies des ongles d'origine médicamenteuse - onycholyse DATA peut se développer à la suite de réactions phototoxiques, surtout si vous prenez de la tétracycline, les fluoroquinolones, les phénothiazines, et psolarenów, mais aussi l'utilisation de médicaments non-stéroïdiens anti-inflammatoires non stéroïdiens (AINS), captopril, les rétinoïdes, le valproate de sodium, et de nombreux agents chimiothérapeutiques tels taxanes (paclitaxel, docetaxel), et les anthracyclines. Le risque de onycholizy chez les patients recevant des médicaments cytotoxiques augmente lorsqu'il est exposé à la lumière du soleil. Onychomadezę provoque la suspension temporaire de l'activité mitotique matrice de l'ongle. À médicaments connus pour provoquer ce trouble doit carbamazépine, le lithium, les rétinoïdes et des agents chimiothérapeutiques tels que la vincristine et cyclophosphamide. Perionyxis, ainsi que de myélome de granulome pyogénique (courir avec la formation d'abcès péri-unguéales douloureuses sur les doigts et les orteils) sont un effet secondaire de l'utilisation générale de rétinoïdes, la lamivudine, indinavir, anticorps monoclonal anti-EGFR (cetuximab, gefitinib). Modification de la couleur de l'ongle provoquée par des médicaments tels que les anthracyclines, les taxanes, le fluorouracile et la zidovudine est causée par une décoloration de l'ongle en tant que résultat de la stimulation des mélanocytes. Cet effet est complètement réversible, et la gravité de la dose correspondante. 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POLEKOWE CHOROBY PAZNOKCI (ang. DRUG-INDUCED NAIL DISEASES)

Zmiany chorobowe paznokci spowodowane stosowaniem niektórych leków zazwyczaj pojawiają się w obrębie kilku z nich (rzadziej natomiast obej...

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